Description

Histidyl-Aspartyl-Glutamyl-Leucine is a synthetic tetrapeptide composed of the amino acids histidine, aspartic acid, glutamic acid, and leucine. This sequence-specific peptide is of significant interest for research and development in advanced biomedical and cosmetic applications due to its potential bioactive properties. It is primarily utilized by R&D laboratories and manufacturers in the pharmaceutical, biotechnology, and high-end cosmetic industries for studying peptide function, stability, and as a potential active ingredient.

Application

• Biomedical Research: Used as a reference standard or intermediate in proteomics, enzymology, and signal transduction pathway studies.
• Pharmaceutical Development: Investigated as a potential active pharmaceutical ingredient (API) or a key fragment in the synthesis of larger therapeutic peptides.
• Cosmetic & Skincare Formulations: Explored for potential anti-aging, moisturizing, or skin-repair properties in high-performance cosmetic products.
• Biochemical Reagent: Serves as a substrate or inhibitor in enzymatic assays and biochemical research.
• Nutritional Science: Studied for its potential role in specialized nutraceuticals or dietary supplements targeting specific metabolic functions.

Basic Information

Product Name	Histidyl-Aspartyl-Glutamyl-Leucine
CAS No.	129623-52-5
Molecular Formula	C23H36N6O10
Molecular Weight	556.57 g/mol
Synonyms	H-Asp-Glu-Leu-OH; HDEL Peptide; Tetrapeptide HDEL; Histidyl-Aspartyl-Glutamyl-Leucine; L-Histidyl-L-α-aspartyl-L-α-glutamyl-L-leucine; HDEL sequence; ER retention signal peptide; Lys-Asp-Glu-Leu (KDEL) analogue
EINECS	Contact for details

Quality Control

Our Histidyl-Aspartyl-Glutamyl-Leucine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets high-purity research-grade standards. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.