Description

(2,5-Difluoro-Phenyl)-Carbamic Acid tert-Butyl Ester is a high-purity, protected aniline derivative of significant importance in advanced organic synthesis. This compound serves as a versatile and critical building block, primarily valued for its role as a Boc-protected intermediate in the development of complex pharmaceutical molecules and agrochemicals. It is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality intermediates for constructing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key Boc-protected aniline precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the difluorophenyl moiety imparts desirable biological activity and metabolic stability.
• Peptide Mimetics & PROTACs: Employed in the construction of peptide backbones and as a linker component in Proteolysis Targeting Chimeras (PROTACs) due to its stable carbamate protection.
• Material Science Research: Acts as a monomer or functionalization agent in the development of specialty polymers and advanced organic materials.
• Chemical Biology Probes: Utilized to synthesize fluorescent tags, affinity labels, and other molecular probes for studying biological systems.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific fluorinated aromatic intermediates.

Basic Information

Product Name	(2,5-Difluoro-Phenyl)-Carbamic Acid tert-Butyl Ester
CAS No.	129589-71-5
Molecular Formula	C11H13F2NO2
Molecular Weight	229.22 g/mol
Synonyms	N-Boc-2,5-difluoroaniline; tert-Butyl (2,5-difluorophenyl)carbamate; 2,5-Difluoroaniline N-Boc derivative; Boc-2,5-difluoroaniline; N-(tert-Butoxycarbonyl)-2,5-difluoroaniline; 1,4-Difluoro-2-((tert-butoxycarbonyl)amino)benzene; BOC-2,5-F2-Ph-NH2; Carbamic acid, N-(2,5-difluorophenyl)-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our (2,5-Difluoro-Phenyl)-Carbamic Acid tert-Butyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality systems are designed to support cGMP (current Good Manufacturing Practice) requirements for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.