Description

Parathyroid Hormone-Related Protein(14-34) Amide is a synthetic peptide fragment corresponding to residues 14-34 of the human parathyroid hormone-related protein (PTHrP) with a C-terminal amide modification. This specific sequence is a crucial research tool for investigating the structure-activity relationships and receptor binding mechanisms of PTHrP, a key regulator of calcium homeostasis and bone metabolism. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in metabolic bone disease research, cancer biology studies, and peptide-based drug discovery programs.

Application

• Biomedical Research: Used as a reference standard and active agent in studies of PTH/PTHrP receptor (PTH1R) signaling pathways.
• Drug Discovery: Serves as a key intermediate or pharmacophore model for developing novel therapeutics targeting osteoporosis, hypercalcemia of malignancy, and other bone-related disorders.
• Assay Development: Employed in the development and validation of competitive binding assays (e.g., ELISA, RIA) and functional cell-based assays to screen for receptor agonists or antagonists.
• Structure-Activity Relationship (SAR) Studies: Critical for mapping the bioactive regions of PTHrP and understanding the contribution of specific amino acid residues to receptor affinity and selectivity.
• Academic & Clinical Research: Supports fundamental research into the role of PTHrP in skeletal development, lactation, and tumor-induced osteolysis.

Basic Information

Product Name	Parathyroid Hormone-Related Protein(14-34) Amide
CAS No.	129476-28-4
Molecular Formula	C108H174N34O30
Molecular Weight	2453.8 g/mol
Synonyms	PTHrP(14-34) amide; Parathyroid Hormone-Related Protein (14-34) amide; PTH-related Protein Fragment 14-34 amide; hPTHrP(14-34)NH2; [Tyr34]PTHrP(14-34) amide (human); PTHRP (14-34) (HUMAN); PTHrP 14-34 amide, human
EINECS	Contact for details

Quality Control

Our Parathyroid Hormone-Related Protein(14-34) Amide is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure high purity and batch-to-batch consistency, meeting the exacting standards required for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), peptide content, amino acid analysis, and mass spectrometry (MS) data. We adhere to stringent quality management protocols to support your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the vial to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Analysis	Within ± 10% of theoretical composition
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.