Description

L-Aspartic Acid, n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-, 1,4-Bis(1,1-Dimethylethyl) Ester is a protected derivative of the amino acid L-aspartic acid, featuring both Fmoc (9-fluorenylmethoxycarbonyl) and tert-butyl ester protecting groups. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled and sequential assembly of complex peptides. It is essential for researchers and manufacturers in pharmaceutical development, proteomics, and the production of therapeutic peptides and APIs.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a key Fmoc-protected aspartic acid derivative for the automated synthesis of peptides.
• Pharmaceutical Intermediates: Used in the research and production of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Biochemical Research: A vital reagent for studying protein structure-function relationships, enzyme substrates, and signal transduction pathways.
• Proteomics and Genomics: Employed in the synthesis of custom peptides for antibody production, epitope mapping, and diagnostic assay development.
• Combinatorial Chemistry: Utilized in libraries for high-throughput screening to discover new bioactive molecules.
• Material Science: Potential use in the synthesis of peptide-conjugated polymers and biomaterials.

Basic Information

Item	Details
Product Name	L-Aspartic Acid, n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-, 1,4-Bis(1,1-Dimethylethyl) Ester
CAS No.	129460-17-9
Molecular Formula	C27H33NO6
Molecular Weight	467.56 g/mol
Synonyms	Fmoc-Asp(OtBu)-OH; Fmoc-L-aspartic acid 4-tert-butyl ester; N-α-Fmoc-L-aspartic acid β-tert-butyl ester; N-(9-Fluorenylmethoxycarbonyl)-L-aspartic acid 1-tert-butyl ester; Fmoc-Asp(OtBu)-OH; Fmoc-Aspart(OtBu)-OH; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]butanedioic acid 4-tert-butyl ester; N-Fmoc-L-aspartic acid β-t-butyl ester
EINECS	Contact for details

Quality Control

Our L-Aspartic Acid, n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-, 1,4-Bis(1,1-Dimethylethyl) Ester is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) with detailed specifications are provided to guarantee batch-to-batch consistency and reliability for your critical research and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	Specific range provided on COA
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.