Description

Fmoc-Glu(Otbu)-Otbu is a protected amino acid derivative widely used as a critical building block in solid-phase peptide synthesis (SPPS). Its value lies in providing orthogonal protection for the glutamic acid side chain, enabling the controlled synthesis of complex peptides and peptidomimetics. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the controlled incorporation of glutamic acid into peptide chains.
• Pharmaceutical R&D: Used in the research and development of novel peptide-based therapeutics, including hormones, antibiotics, and targeted drug conjugates.
• Bioconjugation: Serves as a precursor for creating functionalized peptides used in antibody-drug conjugates (ADCs) and other bioconjugation strategies.
• Combinatorial Chemistry: Employed in the generation of peptide libraries for high-throughput screening and drug discovery.
• Biochemical Research: Utilized in academic and industrial labs for studying protein-protein interactions, enzyme substrates, and signal transduction pathways.
• Production of Glutamate-Containing Peptides: Specifically enables the synthesis of peptides where the precise placement and reactivity of glutamic acid are required.

Basic Information

Product Name	Fmoc-Glu(Otbu)-Otbu
CAS No.	129460-14-6
Molecular Formula	C29H37NO7
Molecular Weight	511.61 g/mol
Synonyms	Fmoc-Glu(OtBu)-OtBu; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-glutamic acid 1,5-di-tert-butyl ester; Fmoc-L-glutamic acid 5-tert-butyl 1-tert-butyl ester; Fmoc-Glu(OtBu)-OH·OtBu; Nα-Fmoc-L-glutamic acid α,γ-di-tert-butyl ester; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)pentanedioic acid 1,5-di-tert-butyl ester; Fmoc-Glu(OtBu)-O-tBu; Fmoc-Glu(OtBu) OtBu ester
EINECS	Contact for details

Quality Control

Our Fmoc-Glu(Otbu)-Otbu is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for sensitive applications like peptide synthesis. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis to confirm enantiomeric integrity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with our stringent specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere (e.g., nitrogen or argon) after each use to maintain stability and prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Specific Rotation	-15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.