Description

N(3)-(Iodoacetyl)-2,3-Diaminopropanoic Acid is a specialized heterobifunctional crosslinking reagent featuring a reactive iodoacetyl group and a primary amine. This compound matters for its ability to create stable thioether bonds with cysteine residues while providing a primary amine handle for further conjugation, making it a critical tool for precise biomolecule modification. It is primarily needed by researchers and manufacturers in bioconjugation, proteomics, and antibody-drug conjugate (ADC) development who require reliable and specific crosslinking strategies.

Application

• Bioconjugation and Protein Labeling: For site-specific modification of cysteine-containing proteins, peptides, and antibodies.
• Antibody-Drug Conjugate (ADC) Linker Chemistry: Serves as a key intermediate for constructing stable, cleavable, or non-cleavable linkers connecting cytotoxic payloads to monoclonal antibodies.
• Immobilization of Biomolecules: Functionalization of surfaces (e.g., chips, beads, plates) for creating biosensors or affinity purification matrices.
• Proteomics Research: Used in crosslinking mass spectrometry (XL-MS) studies to investigate protein-protein interactions and structural dynamics.
• Synthesis of Peptide Mimetics and Drug Candidates: As a building block for introducing iodoacetyl functionality into novel therapeutic compounds.
• Preparation of Fluorescent or Biotinylated Probes: Conjugation of dyes, tags, or other reporter molecules to targeting biomolecules via the amine group.

Basic Information

Product Name	N(3)-(Iodoacetyl)-2,3-Diaminopropanoic Acid
CAS No.	129365-02-2
Molecular Formula	C5H9IN2O3
Molecular Weight	272.04 g/mol
Synonyms	2,3-Diaminopropanoic Acid N(3)-Iodoacetamide; (S)-2,3-Diaminopropionic Acid N3-Iodoacetamide; Iodoacetamidopropylamine; 3-(Iodoacetamido)-L-2,3-diaminopropionic Acid; N3-(Iodoacetyl)-2,3-diaminopropanoic Acid; Iodoacetyl-DAP; Heterobifunctional Crosslinker Iodoacetyl-Amine; L-2,3-Diaminopropionic acid, N3-(iodoacetyl)-
EINECS	Contact for details

Quality Control

Our N(3)-(Iodoacetyl)-2,3-Diaminopropanoic Acid is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry, to ensure it meets the high standards required for sensitive life science applications. Certificates of Analysis (COA) with detailed specifications are available upon request to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are sealed tightly after each use to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95.0%
Water Content (KF)	≤2.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.