Description

(Tyr38,Phe42,46)-Osteocalcin (38-49) (Human) is a synthetic peptide fragment corresponding to residues 38-49 of the human osteocalcin protein, incorporating specific tyrosine and phenylalanine substitutions. This modified sequence is a critical research tool for investigating the structure-function relationships, receptor binding, and signaling pathways of osteocalcin, a key hormone involved in bone metabolism and energy regulation. It is essential for scientists in pharmaceutical R&D, metabolic disease research, and academic biochemistry who require high-purity, well-characterized peptides for assay development and mechanistic studies.

Application

• Biochemical Research: Used as a reference standard or active component in studies exploring osteocalcin's role in bone mineralization and glucose metabolism.
• Assay Development: Serves as a key antigen or competitor in the development and validation of immunoassays (ELISA, RIA) for detecting osteocalcin or its fragments.
• Receptor Binding Studies: Employed in competitive binding assays to characterize the affinity and specificity of osteocalcin for its putative receptors, such as GPRC6A.
• Structure-Activity Relationship (SAR) Analysis: The specific amino acid substitutions make it invaluable for mapping functional epitopes and understanding post-translational modification effects.
• Cell Signaling & In Vitro Studies: Applied in cell culture models to investigate the downstream effects of osteocalcin signaling on osteoblast, adipocyte, or pancreatic β-cell function.
• Peptide Antibody Production: Acts as an immunogen for generating antibodies specific to this region of the osteocalcin molecule.

Basic Information

Item	Details
Product Name	(Tyr38,Phe42,46)-Osteocalcin (38-49) (Human)
CAS No.	129356-77-0
Molecular Formula	C73H98N18O21
Molecular Weight	1563.7 g/mol
Synonyms	Human Osteocalcin (38-49) fragment, Tyr38,Phe42,46-substituted Osteocalcin (38-49); BGP (38-49) (Human, modified); Bone Gla Protein fragment (38-49); OC (38-49) peptide; Carboxylated Osteocalcin fragment; Gla-containing peptide; Research peptide 129356-77-0
EINECS	Contact for details

Quality Control

Every batch of our (Tyr38,Phe42,46)-Osteocalcin (38-49) (Human) is synthesized and purified under stringent conditions to ensure high purity and batch-to-batch consistency, critical for reproducible research results. Quality is verified through a comprehensive suite of analytical techniques including HPLC, MS, and amino acid analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, peptide content, and molecular weight confirmation.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to prevent condensation. Aliquot into single-use vials to minimize repeated freeze-thaw cycles and exposure to air.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Molecular weight confirmed by Mass Spectrometry
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Composition	Conforms to theoretical values (±10%)
Solubility	Soluble in water or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.