Description

Fmoc-Methionine Nca CAS NO 129288-42-2 is a high-purity, protected amino acid derivative specifically designed for solid-phase peptide synthesis (SPPS). This compound serves as a critical building block, enabling the controlled and efficient incorporation of methionine into complex peptide chains. It is an essential raw material for pharmaceutical R&D, biotechnology, and academic laboratories focused on developing novel therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): Primary reagent for the sequential addition of methionine residues using Fmoc-chemistry protocols.
• Pharmaceutical Research: Key intermediate in the development of peptide-based drugs, hormones, and diagnostic agents.
• Bioconjugation: Used to introduce methionine sites for specific labeling or attachment of other functional molecules.
• Combinatorial Chemistry: A vital component in libraries for high-throughput screening of bioactive peptides.
• Academic & Biochemical Studies: Employed in studying protein structure-function relationships, enzyme substrates, and peptide antigens.
• Material Science: Potential use in the synthesis of peptide-polymer hybrids and biomaterials.

Basic Information

Product Name	Fmoc-Methionine Nca
CAS No.	129288-42-2
Molecular Formula	C₂₀H₁₉NO₅S
Molecular Weight	385.43 g/mol
Synonyms	Fmoc-Met-OH; N-(9-Fluorenylmethoxycarbonyl)-L-methionine; (2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-4-methylsulfanylbutanoic acid; Fmoc-L-methionine; N-α-Fmoc-L-methionine; Fmoc-Methionine; 9-Fluorenylmethyloxycarbonyl-L-methionine; N-Fmoc-L-methionine
EINECS	Contact for details

Quality Control

Our Fmoc-Methionine Nca is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR) to ensure it meets the stringent requirements of peptide synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing consistent high purity and reliable performance for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Optical Rotation [α]²⁰D	-20.0° to -24.0° (c=1 in DMF)
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.