Description

Fmoc-Glu(OtBu)-N-Carboxyanhydride is a high-purity, protected amino acid derivative specifically engineered for solid-phase peptide synthesis (SPPS). This compound is a critical building block for the efficient and controlled incorporation of glutamic acid with a protected side chain into peptide sequences, enabling the synthesis of complex biomolecules. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): Primary reagent for the stepwise assembly of peptides containing glutamic acid with a tert-butyl-protected side chain.
• Pharmaceutical R&D: Key intermediate in the research and development of novel peptide-based drugs and active pharmaceutical ingredients (APIs).
• Bioconjugation: Used to introduce glutamic acid residues with orthogonal protecting groups for subsequent labeling or cross-linking reactions.
• Combinatorial Chemistry: A valuable building block in libraries for high-throughput screening of bioactive compounds.
• Academic Research: Fundamental tool in biochemistry and molecular biology laboratories for studying protein structure, function, and interactions.
• Production of Custom Peptides: Enables contract research and manufacturing organizations (CROs/CMOs) to produce specific peptide sequences for clients.

Basic Information

Product Name	Fmoc-Glu(OtBu)-N-Carboxyanhydride
CAS No.	129288-39-7
Molecular Formula	C24H25NO7
Molecular Weight	439.46 g/mol
Synonyms	Fmoc-Glu(OtBu)-NCA; N-(9-Fluorenylmethoxycarbonyl)-L-glutamic acid 5-tert-butyl ester N-carboxyanhydride; Fmoc-L-glutamic acid 5-tert-butyl ester NCA; Fmoc-Glu(OtBu)-NCA; 5-tert-Butyl N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-glutamate N-carboxyanhydride; (4R)-4-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}-5-[(2-methylpropan-2-yl)oxy]-5-oxopentanoic acid, cyclic anhydride; Fmoc-Glu(OtBu)-Anhydride
EINECS	Contact for details

Quality Control

Our Fmoc-Glu(OtBu)-N-Carboxyanhydride is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research and production applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our customers' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, cool place. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	-15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.