Description

n-α-Fmoc-n-δ-Trityl-L-Glutamine n-Carboxyanhydride is a specialized, high-purity N-carboxyanhydride (NCA) derivative used as a key building block in solid-phase peptide synthesis (SPPS). This compound matters for its role in facilitating the efficient and controlled incorporation of protected glutamine residues, which is critical for synthesizing complex peptides and proteins with high fidelity. It is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on developing therapeutic peptides, peptidomimetics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a protected amino acid N-carboxyanhydride for the rapid, racemization-free elongation of peptide chains.
• Pharmaceutical Research & Development: A critical intermediate in the synthesis of peptide-based drug candidates and active pharmaceutical ingredients (APIs).
• Bioconjugation: For the site-specific modification of proteins or other biomolecules by introducing protected glutamine handles.
• Combinatorial Chemistry: Used in libraries for high-throughput screening to discover new bioactive peptides.
• Academic Research: Employed in studies of protein structure-function relationships, enzyme substrates, and receptor ligands.
• Production of Custom Peptides: Essential for contract research organizations (CROs) and CDMOs producing bespoke peptides for clients.

Basic Information

Product Name	n-α-Fmoc-n-δ-Trityl-L-Glutamine n-Carboxyanhydride
CAS No.	129288-38-6
Molecular Formula	C45H38N2O6
Molecular Weight	702.80 g/mol
Synonyms	Fmoc-Gln(Trt)-NCA; Nα-Fmoc-Nδ-trityl-L-glutamine N-carboxyanhydride; (4R)-4-[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-2-oxo-5,5-diphenyl-1,3-oxazolidine-4-carboxylic acid; Fmoc-L-Glutamine(Trityl)-NCA; NCA-Fmoc-Gln(Trt); Fmoc-Gln(Trt)-N-carboxyanhydride; Nα-(9-Fluorenylmethoxycarbonyl)-Nδ-trityl-L-glutamine NCA
EINECS	Contact for details

Quality Control

Our n-α-Fmoc-n-δ-Trityl-L-Glutamine n-Carboxyanhydride is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for sensitive peptide synthesis applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis to confirm enantiomeric integrity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dedicated freezer. This product is hygroscopic (moisture-sensitive); allow the sealed container to equilibrate to room temperature before opening to minimize condensation and exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.