Description

Substance P (6-11), Arg(6)-Trp(7,9)-Me-Phe(8)- is a bioactive peptide fragment derived from the neuropeptide Substance P, specifically encompassing amino acid residues 6 through 11 with key modifications. This compound is a potent and selective agonist for the neurokinin-1 (NK-1) receptor, making it a critical research tool for studying pain signaling, neuroinflammation, and gastrointestinal motility. It is primarily utilized by pharmaceutical researchers, neuroscientists, and contract research organizations (CROs) engaged in preclinical drug discovery and neuropharmacology studies.

Application

• Neuroscience Research: As a selective NK-1 receptor agonist for investigating pain pathways, migraine, and central nervous system disorders.
• Pharmacological Assay Development: Used as a reference standard in high-throughput screening (HTS) and functional assays to identify and characterize NK-1 receptor antagonists.
• Gastrointestinal Physiology Studies: For research on gut motility, secretion, and inflammatory bowel disease models due to Substance P's role in the enteric nervous system.
• Inflammation and Immune Response Research: Studying neurogenic inflammation and the interaction between the nervous and immune systems.
• Cell Signaling Pathways: Elucidating intracellular signaling cascades (e.g., involving phospholipase C and calcium mobilization) activated by NK-1 receptors.
• Reference Standard for Analytical Methods: For method development and validation in HPLC, LC-MS, and other analytical techniques within quality control and research laboratories.

Basic Information

Product Name	Substance P (6-11), Arg(6)-Trp(7,9)-Me-Phe(8)-
CAS No.	129244-81-1
Molecular Formula	C48H65N15O7
Molecular Weight	964.1 g/mol
Synonyms	Substance P (6-11) amide; [Arg6, Trp7,9, N-Me-Phe8]-Substance P (6-11); [pGlu6, N-Me-Phe8, Trp9]-Substance P (6-11); SP (6-11); NK-1 Receptor Agonist (6-11); Neurokinin-1 Receptor Agonist Fragment; Arg-Pro-Lys-Pro-N-Me-Phe-Gln-Trp-NH2; [pGlu6, MePhe8, Trp9]-Substance P(6-11)
EINECS	Contact for details

Quality Control

Our peptide products are manufactured under strict quality management systems. Each batch of Substance P (6-11), Arg(6)-Trp(7,9)-Me-Phe(8)- undergoes rigorous analytical testing, including HPLC for purity determination, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). Certificates of Analysis (COA) detailing purity, peptide content, and analytical data are provided to ensure compliance with research-grade standards and support reproducible scientific results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.