Description

Fmoc-Pro-Pro-Oh CAS NO 129223-22-9 is a high-purity, protected dipeptide building block essential for solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring precise control over peptide chain assembly, particularly for sequences containing proline residues. It is primarily utilized by the pharmaceutical, biotechnology, and academic research sectors for developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the sequential construction of custom peptide sequences in automated synthesizers.
• Pharmaceutical Research: Used in the discovery and development of novel peptide-based drugs targeting various diseases.
• Bioconjugation: Serves as a precursor for creating peptide-protein or peptide-small molecule conjugates for targeted therapies.
• Biochemical Probe Development: Incorporated into peptides used to study enzyme function, protein-protein interactions, and cellular signaling pathways.
• Combinatorial Chemistry Libraries: A valuable building block for generating diverse peptide libraries for high-throughput screening.
• Academic & Contract Research: Supports fundamental research in organic chemistry, medicinal chemistry, and structural biology.

Basic Information

Product Name	Fmoc-Pro-Pro-Oh
CAS No.	129223-22-9
Molecular Formula	C₂₅H₂₆N₂O₅
Molecular Weight	434.49 g/mol
Synonyms	Fmoc-Pro-Pro-OH; Fmoc-L-Prolyl-L-proline; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-prolyl-L-proline; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-1-((S)-pyrrolidine-2-carbonyl)pyrrolidine-1-carboxylic acid; Fmoc-Pro-Pro; Fmoc-Pro-Pro-COOH; N-Fmoc-L-prolyl-L-proline; Fmoc-Pro-Pro dipeptide
EINECS	Contact for details

Quality Control

Our Fmoc-Pro-Pro-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, typically ≥98% (HPLC). Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for fine chemicals and can support development under cGMP guidelines for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.