Description

Autocamtide-2 CAS NO 129198-88-5 is a synthetic peptide substrate specifically designed for the study of calcium/calmodulin-dependent protein kinase II (CaMKII). This compound matters as a critical research tool for elucidating the role of CaMKII in cellular signaling pathways, particularly in the brain and heart. It is essential for researchers and pharmaceutical developers in the fields of neuroscience, cardiology, and drug discovery who require a reliable and specific substrate for kinase activity assays and inhibitor screening.

Application

• CaMKII Enzyme Activity Assays: Primary substrate for measuring the phosphorylation activity of CaMKII isoforms in vitro.
• High-Throughput Screening (HTS): Used in drug discovery platforms to identify and characterize novel CaMKII inhibitors for therapeutic development.
• Biochemical Research: Fundamental tool for studying CaMKII kinetics, activation mechanisms, and substrate specificity in signal transduction studies.
• Neuroscience Research: Investigating the role of CaMKII in synaptic plasticity, memory formation, and neurological disorders.
• Cardiovascular Research: Studying CaMKII signaling in cardiac muscle contraction, arrhythmias, and heart failure models.
• Diagnostic Kit Development: A key component in developing ELISA or other assay kits for research and clinical analysis of kinase-related pathways.

Basic Information

Product Name	Autocamtide-2
CAS No.	129198-88-5
Molecular Formula	C41H71N13O12
Molecular Weight	914.1 g/mol
Synonyms	Autocamtide-2; CaMKII Substrate Peptide; KKALRRQETVDAL; Autocamtide 2; CaMKII Inhibitory Peptide; CaM Kinase II Substrate (281-309); CaMKII(281-309); Autocamptide-2; KKALRRQETVDAL-NH2 (C-terminal amide form)
EINECS	Contact for details

Quality Control

Our Autocamtide-2 is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes rigorous analytical testing including HPLC for purity assessment and mass spectrometry for identity confirmation. Certificates of Analysis (COA) detailing purity, peptide content, and solvent residues are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Solvent Residues	Meets ICH guidelines
Water Content (KF)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.