Description

Spantide II is a potent and selective synthetic peptide antagonist of the neurokinin-1 (NK1) receptor, widely used in neuroscience and pharmacological research. Its primary value lies in its ability to specifically block substance P-mediated signaling, making it an essential tool for studying pain pathways, neurogenic inflammation, and central nervous system disorders. This high-purity compound is critical for researchers and developers in the pharmaceutical, biotechnology, and academic sectors who require reliable, well-characterized biochemical tools for receptor binding studies, *in vitro* assays, and preclinical investigations.

Application

• Neuroscience Research: A key reagent for investigating the role of substance P and NK1 receptors in pain transmission, migraine, anxiety, and depression.
• Pharmacological Studies: Used in *in vitro* and *in vivo* models to evaluate the efficacy of novel analgesic and anti-inflammatory drug candidates.
• Signal Transduction Research: Employed to dissect G-protein coupled receptor (GPCR) pathways and intracellular signaling mechanisms related to neurokinin receptors.
• Inflammation Models: Applied in studies of neurogenic inflammation, arthritis, and inflammatory bowel disease to understand the neuroimmune axis.
• Biochemical Assay Development: Serves as a reference standard and control in high-throughput screening (HTS) and receptor binding assays (RBA).
• Academic & Institutional R&D: Supports fundamental research in university and government laboratories focused on neuropeptide physiology.

Basic Information

Product Name	Spantide II
CAS No.	129176-97-2
Molecular Formula	C~84~H~122~N~24~O~19~
Molecular Weight	1795.0 g/mol
Synonyms	Spantide II; [D-Trp^7,9,10] Substance P (4-11); [D-Trp^7,9,10]-SP (4-11); Arg-Pro-Lys-Pro-D-Trp-Gln-D-Trp-Phe-D-Trp-Leu-Leu-NH2; NK1 Receptor Antagonist (Spantide II); Tachykinin NK1 Receptor Antagonist; Neurokinin-1 Receptor Antagonist (Peptide); Substance P Antagonist (Spantide II)
EINECS	Contact for details

Quality Control

Our Spantide II is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). A detailed Certificate of Analysis (COA) documenting purity, peptide content, and solvent residues is provided with every shipment to support your regulatory and documentation requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by AAA)
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.