Description

Corticotropin-Releasing Hormone (12-41), Phe(12)-Nle(21,38)- CAS NO 129133-41-1 is a synthetic peptide fragment of the corticotropin-releasing hormone (CRH), specifically designed for advanced biochemical and pharmacological research. This modified analog is critical for studying the hypothalamic-pituitary-adrenal (HPA) axis, receptor binding mechanisms, and stress response pathways. It is an essential tool for researchers and developers in the fields of neuroscience, endocrinology, and pharmaceutical discovery.

Application

• Neuroscientific Research: Investigation of stress response, anxiety, and depression mechanisms via the HPA axis.
• Endocrinology Studies: Analysis of CRH receptor (CRHR1/CRHR2) binding affinity, specificity, and signal transduction.
• Pharmaceutical Development: Serving as a reference standard or lead compound in the development of novel therapeutics for stress-related disorders.
• Biochemical Assays: Use in competitive binding assays (e.g., RIA, ELISA) and functional cellular assays to characterize receptor activity.
• Academic & Institutional Research: Fundamental research in universities and institutes focusing on peptide hormone function and neuroendocrinology.

Basic Information

Product Name	Corticotropin-Releasing Hormone (12-41), Phe(12)-Nle(21,38)-
CAS No.	129133-41-1
Molecular Formula	C152H246N44O42
Molecular Weight	~3350.9 g/mol
Synonyms	CRH (12-41), Phe(12)-Nle(21,38)-; h/rCRH(12-41); Corticotropin Releasing Factor (12-41), Phe(12)-Nle(21,38)-; CRF (12-41), Phe(12)-Nle(21,38)-; [Phe12,Nle21,38]hCRH(12-41); [Phe12,Nle21,38]-Corticotropin-Releasing Hormone (12-41); CRH Antagonist Fragment; Astressin analog
EINECS	Contact for details

Quality Control

Our peptide products are manufactured and tested under stringent quality management systems. Certificates of Analysis (COA) are provided with each batch, detailing purity, identity, and content. Quality is assured through advanced analytical techniques including HPLC and MS to meet the exacting standards required for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Molecular weight confirmed by mass spectrometry
Purity (HPLC)	≥ 95%
Assay (Peptide Content)	≥ 80%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.