Description

.Mu.-Conotoxin G Iiia CAS NO 129129-65-3 is a highly selective and potent peptide neurotoxin derived from the venom of marine cone snails. This compound is a critical research tool for studying voltage-gated sodium channels, particularly the Nav1.4 subtype, which is essential for understanding neuromuscular signaling and related pathologies. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in neuroscience, ion channel pharmacology, and the development of novel therapeutics for pain and neuromuscular disorders.

Application

• Neuroscience Research: A selective blocker for studying the function and distribution of skeletal muscle sodium channels (Nav1.4).
• Ion Channel Pharmacology: Used as a reference standard in high-throughput screening assays to identify and characterize new channel modulators.
• Drug Discovery: Serves as a molecular template for the design and development of novel analgesic and neuroprotective agents.
• Physiological Studies: Employed in electrophysiology experiments to investigate neuromuscular junction transmission and excitability.
• Toxicology & Venom Research: Used as a benchmark compound in comparative studies of conotoxin bioactivity and specificity.
• Biochemical Reagent: Acts as a precise tool for the isolation and characterization of sodium channel proteins in complex biological samples.

Basic Information

Product Name	.Mu.-Conotoxin G Iiia
CAS No.	129129-65-3
Molecular Formula	C96H147N33O27S6
Molecular Weight	~2287.7 g/mol
Synonyms	μ-Conotoxin GIIIA; Mu-Conotoxin GIIIA; Conotoxin GIIIA; μ-CTX GIIIA; GIIIA; Mu Conotoxin from Conus geographus; μ-Conotoxin from Conus geographus; Geographutoxin II
EINECS	Contact for details

Quality Control

Our .Mu.-Conotoxin G Iiia is produced and handled under stringent quality protocols to ensure batch-to-batch consistency and high biological activity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, peptide content, and bioactivity. We adhere to relevant standards for research-grade biochemicals, ensuring reliability for your critical experiments. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant or under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Biological Activity (IC50)	Specified per batch (Nav1.4 blockade)
Solubility	Soluble in aqueous buffers or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.