Description

Echistatin CAS NO 129038-42-2 is a potent and highly specific disintegrin peptide, originally isolated from the venom of the saw-scaled viper (*Echis carinatus*). This compound is a critical research tool for its ability to selectively inhibit the integrin αIIbβ3 (GPIIb/IIIa), a key receptor in platelet aggregation. As such, it is indispensable for researchers in life sciences and pharmaceutical development who are investigating thrombosis, hemostasis, angiogenesis, and cell adhesion mechanisms. Its high specificity makes it a valuable standard in biochemical assays and a lead compound for antithrombotic drug discovery.

Application

• Biomedical Research: Used as a specific antagonist to study the structure, function, and signaling pathways of the αIIbβ3 integrin receptor in platelets and other cell types.
• Thrombosis & Hemostasis Studies: Essential for in vitro and ex vivo experiments investigating platelet aggregation, clot formation, and the development of novel antithrombotic agents.
• Cell Adhesion & Migration Assays: Applied in cancer research and vascular biology to examine the role of integrins in tumor metastasis, angiogenesis, and wound healing processes.
• Pharmaceutical Development: Serves as a reference standard and a molecular template for the design and screening of new antiplatelet and anticancer therapeutics.
• Biochemical Reagent: Utilized in enzyme-linked immunosorbent assays (ELISAs), flow cytometry, and other diagnostic or research kits targeting integrin activity.

Basic Information

Product Name	Echistatin
CAS No.	129038-42-2
Molecular Formula	C184H273N55O57S6
Molecular Weight	~ 5.4 kDa
Synonyms	Echistatin (Echis carinatus); Platelet aggregation inhibitor peptide; αIIbβ3 integrin inhibitor; GPIIb-IIIa antagonist; Disintegrin Echistatin; ECIST_HC016
EINECS	Contact for details

Quality Control

Our Echistatin is produced and tested under stringent conditions to ensure the highest standards of purity and biological activity, suitable for critical research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, peptide content, endotoxin levels, and functional activity in standardized assays. We adhere to GMP-like guidelines for peptide synthesis and purification to guarantee batch-to-batch consistency and reliability.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized powder at -20°C or below. Reconstituted solutions should be aliquoted and stored at -80°C to prevent repeated freeze-thaw cycles. This product is hygroscopic (moisture-sensitive); ensure the vial is at room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Endotoxin Level	< 1.0 EU/mg
Biological Activity (IC50)	Specified per batch (typically in nM range for αIIbβ3 inhibition)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.