Description

Cyclo(-Gly-Arg-Gly-Asp-Ser-Pro-Ala) is a synthetic, cyclic heptapeptide featuring the RGD (Arg-Gly-Asp) cell adhesion motif. This compound matters as a highly specific and potent inhibitor of integrin-mediated cell adhesion, making it a critical research tool for studying cellular interactions, angiogenesis, and metastasis. It is primarily needed by researchers and developers in the fields of biomedical research, drug discovery, and bioconjugation, where precise modulation of cell signaling pathways is required.

Application

• Biomedical Research: Used as a specific antagonist to study integrin function in cell adhesion, migration, and signaling pathways.
• Angiogenesis Studies: Applied in research models to inhibit neovascularization by blocking integrin receptors on endothelial cells.
• Cancer Research: Utilized to investigate the role of integrins in tumor metastasis and as a potential template for anti-cancer therapeutic development.
• Biomaterial Functionalization: Serves as a surface coating agent to promote or control specific cell attachment on scaffolds and medical implants.
• Drug Discovery: Acts as a lead compound or reference standard in the development of novel anti-thrombotic and anti-inflammatory agents.
• Biochemical Assays: Employed as a competitive inhibitor in ELISA and other plate-based adhesion assays to validate specificity.

Basic Information

Product Name	Cyclo(-Gly-Arg-Gly-Asp-Ser-Pro-Ala)
CAS No.	128857-77-2
Molecular Formula	C29H46N12O11
Molecular Weight	714.8 g/mol
Synonyms	c(RGDFSPA); Cyclo(GRGDSPA); Cyclic GRGDSPA Peptide; Arg-Gly-Asp (RGD) Cyclic Peptide; cRGD; Integrin Inhibitor Peptide; H-Cyclo(Gly-Arg-Gly-Asp-Ser-Pro-Ala)-OH; Cyclo(Gly-Arg-Gly-Asp-Ser-Pro-Ala)
EINECS	Contact for details

Quality Control

Our Cyclo(-Gly-Arg-Gly-Asp-Ser-Pro-Ala) is produced under stringent conditions to ensure high purity and batch-to-batch consistency suitable for research applications. All products undergo rigorous quality testing, including HPLC, MS, and amino acid analysis, to verify identity and purity. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.