Description

Suc-Ala-His-Pro-Phe-Pna is a synthetic peptide substrate designed for biochemical and pharmaceutical research. This compound is a critical tool for studying enzyme kinetics and inhibition, particularly for proteases like dipeptidyl peptidase IV (DPP-IV). It serves as a high-purity, reliable reagent for researchers and manufacturers in the life sciences sector requiring precise analytical standards and intermediates for diagnostic or therapeutic development.

Application

• Enzyme Substrate for DPP-IV Assays: Primary use as a chromogenic or fluorogenic substrate for measuring dipeptidyl peptidase IV (DPP-IV/CD26) activity in kinetic studies.
• Pharmaceutical Research & Development: Key intermediate or reference standard in the discovery and screening of DPP-IV inhibitors for metabolic disease therapeutics (e.g., type 2 diabetes).
• Diagnostic Kit Manufacturing: Essential component in the formulation of in-vitro diagnostic (IVD) kits for clinical laboratory testing of enzymatic activity.
• Biochemical Research: Used in academic and industrial laboratories for fundamental research on protease function, signal transduction, and cell biology.
• Quality Control & Validation: Serves as a calibrated standard for method validation, equipment calibration, and quality control in analytical laboratories.

Basic Information

Product Name	Suc-Ala-His-Pro-Phe-Pna
CAS No.	128802-75-5
Molecular Formula	C₃₃H₄₂N₁₀O₉
Molecular Weight	722.77 g/mol
Synonyms	Suc-Ala-His-Pro-Phe-pNA; Suc-AHPF-pNA; N-Succinyl-Ala-His-Pro-Phe-p-nitroanilide; Succinyl-Alanyl-Histidyl-Prolyl-Phenylalanyl-p-Nitroanilide; DPP-IV Substrate; Dipeptidyl Peptidase IV Substrate; GPI 10447 (research code); 4-Nitroanilide derivative of Suc-AHPF
EINECS	Contact for details

Quality Control

Our Suc-Ala-His-Pro-Phe-Pna is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification, mass spectrometry for identity confirmation, and stringent controls for moisture and related substances. A Certificate of Analysis (COA) detailing all specifications and test results is provided to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.