Description

iso-Atrial Natriuretic Peptide Rat is a synthetic peptide analog of the endogenous cardiac hormone, atrial natriuretic peptide (ANP). This compound is a critical research tool for studying cardiovascular physiology, renal function, and the natriuretic peptide receptor system. It is primarily utilized by pharmaceutical researchers, academic institutions, and contract research organizations (CROs) engaged in preclinical cardiovascular and metabolic disease studies.

Application

• Cardiovascular Research: Investigation of blood pressure regulation, vasodilation, and heart failure models.
• Renal Physiology Studies: Research into natriuresis, diuresis, and electrolyte balance mechanisms.
• Receptor Binding Assays: Used as a reference standard or ligand in studies targeting natriuretic peptide receptors (NPR-A, NPR-B, NPR-C).
• Biochemical Pathway Analysis: Elucidation of the cGMP signaling pathway activated by ANP.
• Drug Discovery & Development: Serving as a pharmacological tool for screening and validating novel therapeutic candidates targeting hypertension and heart failure.
• In Vitro & Ex Vivo Studies: Application in cell-based assays and isolated tissue preparations to assess biological activity.

Basic Information

Product Name	iso-Atrial Natriuretic Peptide Rat
CAS No.	128754-03-0
Molecular Formula	C127H204N42O39S4
Molecular Weight	~2950.5 g/mol
Synonyms	iso-ANP (1-28), rat; Atriopeptin (iso-form); iso-ANP Rat; iso-Atrial Natriuretic Factor, rat; ANP (iso-form); Cardionatrin I (iso-form); iso-ANP; iso-ANP (rat); iso-Atriopeptin 28
EINECS	Contact for details

Quality Control

Our iso-Atrial Natriuretic Peptide Rat is produced under stringent conditions to ensure high purity and batch-to-batch consistency for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination and Mass Spectrometry (MS) for identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, peptide content, and other critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Biological Activity	Determined by in vitro assay (e.g., cGMP accumulation)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.