Description

L-Ornithine-[2,3-3H] is a high-specific-activity, tritium-labeled derivative of the amino acid L-ornithine, essential for advanced biochemical and pharmacological research. This radiolabeled compound is critical for conducting precise metabolic pathway tracing, pharmacokinetic studies, and receptor binding assays where high sensitivity and specificity are required. It is primarily utilized by research scientists and quality control laboratories in the pharmaceutical, biotechnology, and academic sectors focused on urea cycle function, polyamine biosynthesis, and liver metabolism.

Application

• Metabolic Pathway Tracing: Used as a radiotracer to study the urea cycle, arginine biosynthesis, and polyamine (putrescine) metabolism in vivo and in vitro.
• Pharmacokinetic/ADME Studies: Employed in Absorption, Distribution, Metabolism, and Excretion (ADME) research to track the fate of ornithine and ornithine-based drug candidates.
• Enzyme Assay Substrate: Serves as a labeled substrate for assays involving enzymes like ornithine transcarbamylase (OTC) and ornithine decarboxylase (ODC).
• Receptor Binding & Uptake Studies: Facilitates research into amino acid transporter function and receptor-ligand interactions in hepatic and renal tissues.
• Biomedical Research: Applied in studies related to hyperammonemia, liver cirrhosis, wound healing, and muscle metabolism.
• Quality Control & Reference Standard: Acts as an internal standard in analytical methods such as Liquid Chromatography-Mass Spectrometry (LC-MS) for quantifying unlabeled ornithine.

Basic Information

Product Name	L-Ornithine-[2,3-3H]
CAS No.	128551-39-3
Molecular Formula	C5H12N2O2 (³H-labeled)
Molecular Weight	~135.2 g/mol (varies with specific activity)
Synonyms	(2S)-2,5-Diaminopentanoic-2,3-³H acid; L-2,5-Diaminovaleric-2,3-³H acid; Ornithine-2,3-t; Tritiated L-Ornithine; [2,3-³H]-L-Ornithine; ³H-L-Ornithine; (S)-Ornithine-[2,3-³H]
EINECS	Contact for details

Quality Control

Every batch of L-Ornithine-[2,3-3H] is manufactured and analyzed under strict quality systems to ensure radiochemical purity, specific activity, and chemical identity. Comprehensive Certificates of Analysis (COA) are provided, detailing results for key parameters including radiochemical purity (by HPLC), specific activity (Ci/mmol), chemical purity, and solvent composition. Our production adheres to cGMP guidelines where applicable, supporting its use in regulated preclinical research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in the original solvent as specified on the label. This product is hygroscopic (moisture-sensitive). For long-term stability, avoid repeated freeze-thaw cycles and store under inert atmosphere when necessary. Handle and dispose of in accordance with all applicable radiation safety regulations.

Specification

Item	Specification
Appearance	Clear, colorless to slightly yellow solution
Identification (HPLC, MS)	Conforms to reference standard
Radiochemical Purity (HPLC)	≥ 95%
Specific Activity	10-80 Ci/mmol (Contact for exact value)
Chemical Purity (HPLC)	≥ 98%
Solvent	Ethanol:Water or as specified
Concentration	1 mCi/mL (typical)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.