Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-8-(Difluoromethoxy)-6-Fluoro-1,4-Dihydro-7-(3-Methyl-1-Piperazinyl)-4-Oxo-, Monohydrochloride, (S)- is a high-purity, non-racemic pharmaceutical intermediate of significant commercial importance. This compound is valued for its role as a key chiral building block in the synthesis of advanced active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and manufacturers in the pharmaceutical and biotechnology sectors engaged in the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical chiral precursor in the synthesis of complex, fluorinated quinolone-based antibiotics and other therapeutic molecules.
• API Development: Used in research and process development for new Active Pharmaceutical Ingredients (APIs), particularly those targeting bacterial infections.
• Process Chemistry: Serves as a key starting material (KSM) or advanced intermediate in multi-step organic synthesis for scale-up and manufacturing.
• Chemical Research: Utilized in academic and industrial R&D for studying structure-activity relationships (SAR) and developing new medicinal chemistry compounds.
• GMP Manufacturing: Supplied under controlled conditions for use in Good Manufacturing Practice (GMP) compliant production of clinical trial materials and commercial drugs.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-8-(Difluoromethoxy)-6-Fluoro-1,4-Dihydro-7-(3-Methyl-1-Piperazinyl)-4-Oxo-, Monohydrochloride, (S)-
CAS No.	128427-55-4
Molecular Formula	C19H21F3N3O4 • HCl
Molecular Weight	455.85 g/mol (Free base: 419.39 g/mol)
Synonyms	(S)-1-Cyclopropyl-8-(difluoromethoxy)-6-fluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic Acid Monohydrochloride; (S)-Ofloxacin Intermediate; Levofloxacin Related Compound; (S)-DR-3355; (3S)-9-Fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic Acid Hydrochloride Derivative; 1-Cyclopropyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxoquinoline-3-carboxylic Acid Derivative Hydrochloride
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and high chemical purity. All material is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as chiral purity, chemical assay, and impurity profiles. We support development and manufacturing needs with specifications that can align with ICH guidelines and customer-specific requirements for pharmaceutical R&D and GMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (S-enantiomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.