Description

1-Cyclopropyl-6,7-Difluoro-8-Difluoromethoxy-4-Oxo-3-Quinoline Carboxylic Acid is a high-purity advanced pharmaceutical intermediate (API intermediate) of significant commercial importance. Its core value lies in its role as a critical building block in the synthesis of modern fluoroquinolone antibiotics, contributing essential structural features for enhanced antimicrobial activity and spectrum. This compound is primarily needed by pharmaceutical R&D laboratories, fine chemical manufacturers, and contract development and manufacturing organizations (CDMOs) engaged in the production of next-generation antibacterial agents.

Application

• Key Intermediate for Fluoroquinolone Antibiotics: Serves as a crucial precursor in the synthesis of advanced broad-spectrum antibacterial agents.
• Pharmaceutical Research & Development: Used in medicinal chemistry for the design and development of new quinolone-based therapeutic candidates.
• Active Pharmaceutical Ingredient (API) Manufacturing: Integrated into scaled-up production processes for final drug substance synthesis under GMP conditions.
• Process Chemistry & Optimization: Employed in route scouting and process improvement studies for more efficient antibiotic manufacturing.
• Reference Standard: Utilized as an analytical standard for quality control and regulatory submissions in antibiotic production.
• Fine Chemical Synthesis: Acts as a specialized building block for creating complex molecules with the difluoromethoxyquinolone core.

Basic Information

Product Name	1-Cyclopropyl-6,7-Difluoro-8-Difluoromethoxy-4-Oxo-3-Quinoline Carboxylic Acid
CAS No.	128426-95-9
Molecular Formula	C₁₅H₁₀F₄NO₅
Molecular Weight	360.24 g/mol
Synonyms	1-Cyclopropyl-6,7-difluoro-8-(difluoromethoxy)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 8-(Difluoromethoxy)-1-cyclopropyl-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid; Gatifloxacin Intermediate; AM-1155 Intermediate; (±)-1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-(difluoromethoxy)-4-oxo-3-quinolinecarboxylic acid; 3-Quinolinecarboxylic acid, 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-(difluoromethoxy)-4-oxo-; GTFX Intermediate
EINECS	Contact for details

Quality Control

Our 1-Cyclopropyl-6,7-Difluoro-8-Difluoromethoxy-4-Oxo-3-Quinoline Carboxylic Acid is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical applications. All products undergo rigorous analytical testing, including HPLC for assay and impurity profiling, to meet stringent customer specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and related substances is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The container should be kept tightly sealed to protect from moisture. Keep away from strong alkalis and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.