Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-8-(Difluoromethoxy)-6,7-Difluoro-1,4-Dihydro-4-Oxo-, Ethyl Ester is a high-purity, advanced pharmaceutical intermediate of significant commercial importance. This compound is valued for its role as a key building block in the synthesis of novel, potent antibacterial agents, particularly fluoroquinolone antibiotics. It is essential for R&D and manufacturing within the global pharmaceutical and fine chemical industries, where precise molecular structure and consistent quality are critical for successful drug development and regulatory approval.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of next-generation fluoroquinolone antibiotics, such as delafloxacin and other broad-spectrum antibacterial agents.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the final chemical steps to construct the core quinoline scaffold of advanced therapeutic compounds.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and the discovery of new antimicrobial entities.
• Fine Chemical Manufacturing: Employed in custom synthesis and contract manufacturing organizations (CMOs) for producing high-value, specialty chemicals.
• Biochemical Research: Used as a reference standard or inhibitor in studies targeting bacterial DNA gyrase and topoisomerase IV enzymes.

Basic Information

Item	Details
Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-8-(Difluoromethoxy)-6,7-Difluoro-1,4-Dihydro-4-Oxo-, Ethyl Ester
CAS No.	128426-94-8
Molecular Formula	C₁₆H₁₃F₄NO₄
Molecular Weight	359.28 g/mol
Synonyms	Ethyl 1-Cyclopropyl-8-(difluoromethoxy)-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate; Delafloxacin Intermediate; 1-Cyclopropyl-8-(difluoromethoxy)-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid Ethyl Ester; ABT-492 Intermediate; WCK 771 Intermediate; RX-3341 Intermediate; 3-Quinolinecarboxylic acid, 1-cyclopropyl-8-(difluoromethoxy)-6,7-difluoro-1,4-dihydro-4-oxo-, ethyl ester
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarboxylic Acid, 1-Cyclopropyl-8-(Difluoromethoxy)-6,7-Difluoro-1,4-Dihydro-4-Oxo-, Ethyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity suitable for pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.