Description

Parathyroid-Hormone-Related Protein(1-108) CAS NO 128282-00-8 is a specific, high-purity fragment of the full-length parathyroid hormone-related protein (PTHrP), a critical regulatory peptide. This fragment is essential for advanced biomedical research and diagnostic development, particularly in studies of calcium metabolism, bone biology, and cancer. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and manufacturers of in-vitro diagnostic (IVD) kits.

Application

• Biochemical Research: Used as a reference standard and active agent in studies of PTHrP signaling pathways, receptor binding assays, and calcium homeostasis.
• Diagnostic Kit Development: Serves as a critical antigen and calibrator in the development and validation of immunoassays (ELISA, CLIA, RIA) for detecting PTHrP levels in clinical samples.
• Pharmaceutical R&D: Employed in drug discovery programs targeting diseases related to bone metabolism, such as osteoporosis and humoral hypercalcemia of malignancy (HHM).
• Cell Culture & In Vitro Studies: Applied in cell-based assays to investigate the biological effects of PTHrP on osteoblasts, chondrocytes, and cancer cells.
• Antibody Production: Acts as an immunogen for generating specific polyclonal or monoclonal antibodies against PTHrP.
• Quality Control: Used as a system suitability standard in the quality control testing of related therapeutic proteins or diagnostic reagents.

Basic Information

Item	Details
Product Name	Parathyroid-Hormone-Related Protein(1-108)
CAS No.	128282-00-8
Molecular Formula	C530H852N158O163S2 (Approximate)
Molecular Weight	~12100 Da (Approximate)
Synonyms	PTHrP(1-108); Parathyroid Hormone-Related Protein Fragment (1-108); PTHLH(1-108); Hypercalcemia of malignancy factor; HHM factor; PLP; Osteostatin precursor; PTH-related peptide (1-108); Recombinant human PTHrP(1-108)
EINECS	Contact for details

Quality Control

Our Parathyroid-Hormone-Related Protein(1-108) is manufactured under stringent conditions to ensure high purity and biological activity. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry for identity confirmation, and bioassay for functional validation. Certificates of Analysis (COA) detailing all specifications are provided to guarantee traceability and consistency for your research and development needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a dry environment before opening to minimize moisture absorption. Aliquot into working solutions to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	> 70% (by weight)
Biological Activity	Determined by cell-based assay (Contact for details)
Endotoxin Level	< 1.0 EU/μg
Solubility	Soluble in water or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.