Description

Parathyroid-Hormone-Related Protein(1-84) CAS NO 128280-44-4 is a high-purity, biologically active polypeptide fragment that corresponds to the first 84 amino acids of the full-length Parathyroid Hormone-Related Protein (PTHrP). This specific sequence is critical for research and development due to its role in studying calcium metabolism, bone biology, and associated endocrine pathways. It is an essential reagent for pharmaceutical R&D, academic research, and diagnostic assay development targeting hypercalcemia of malignancy and other PTHrP-mediated conditions.

Application

• Biomedical Research: Used as a reference standard and active agent in studies of calcium and phosphate homeostasis, bone formation, and resorption.
• Pharmaceutical Development: Serves as a key intermediate or reference material in the development of therapeutic agents and diagnostics for bone disorders and cancers associated with PTHrP.
• Assay & Diagnostic Kits: Employed as a calibrated standard in immunoassays (ELISA, RIA) to detect and quantify PTHrP levels in clinical and research samples.
• Cell Biology Studies: Utilized to investigate PTHrP receptor (PTH1R) signaling, cell proliferation, and differentiation in various cell lines.
• Quality Control: Acts as a system suitability standard in the quality control of related biopharmaceutical products and diagnostic reagents.

Basic Information

Product Name	Parathyroid-Hormone-Related Protein(1-84)
CAS No.	128280-44-4
Molecular Formula	C390H637N113O118S2
Molecular Weight	Approx. 9000 Da
Synonyms	PTHrP(1-84); Parathyroid Hormone-Related Protein (1-84); PTHLH(1-84); Hypercalcemic factor; Osteostatin; Humoral hypercalcemia of malignancy factor; PTH-related peptide; PLP
EINECS	Contact for details

Quality Control

Our Parathyroid-Hormone-Related Protein(1-84) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, mass spectrometry for identity confirmation, and biological activity assays to ensure consistency and performance. Certificates of Analysis (COA) detailing purity, endotoxin levels, and specific activity are provided to guarantee compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted solutions should be aliquoted and stored at -70°C or below to prevent repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere or desiccant after each use.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0%
Specific Activity	Contact for details
Endotoxin Level	< 1.0 EU/µg
Solubility	Soluble in water or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.