Description

Parathyroid Hormone-Related Protein(1-36)Amide, N(Alpha)-(4-Azido-2-Nitrophenyl)-Ala(1)-Tyr(36)- is a chemically modified, bioactive peptide fragment designed for advanced biochemical research and development. This compound is a critical tool for studying the structure, function, and signaling pathways of parathyroid hormone-related protein (PTHrP), a key regulator of calcium homeostasis and bone metabolism. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies focused on endocrinology, bone disease research, and the development of novel therapeutic agents.

Application

• Biochemical Research: Used as a high-affinity probe or ligand in receptor binding assays and signal transduction studies related to PTH/PTHrP receptors.
• Photocrosslinking Studies: The incorporated 4-azido-2-nitrophenyl group enables the compound to act as a photoaffinity label for identifying and characterizing protein-protein interactions and receptor binding sites.
• Structure-Activity Relationship (SAR) Analysis: Serves as a key intermediate or reference standard for investigating the effects of specific modifications on peptide bioactivity and stability.
• Drug Discovery & Development: Employed in screening platforms and preclinical research for metabolic bone disorders, such as osteoporosis and hypercalcemia of malignancy.
• Diagnostic Development: Potential use in the development of immunoassays or other diagnostic tools for conditions involving PTHrP dysregulation.

Basic Information

Item	Details
Product Name	Parathyroid Hormone-Related Protein(1-36)Amide, N(Alpha)-(4-Azido-2-Nitrophenyl)-Ala(1)-Tyr(36)-
CAS No.	128269-73-8
Molecular Formula	C201H280N62O57S2
Molecular Weight	4538.8 g/mol (approx.)
Synonyms	PTHrP(1-36) amide, ANP-modified; N(α)-(4-Azido-2-nitrophenyl)-PTHrP(1-36) amide; Photoactivatable PTHrP(1-36); PTHrP (1-36), N(alpha)-(4-azido-2-nitrophenyl)-Ala(1)-Tyr(36) amide; Parathyroid hormone-like protein (1-36) amide derivative; ANP-PTHrP(1-36)NH2; Photoreactive PTHrP analog; CAS 128269-73-8
EINECS	Contact for details

Quality Control

Our Parathyroid Hormone-Related Protein(1-36)Amide derivative is produced and controlled under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot is subjected to comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). A detailed Certificate of Analysis (COA) documenting purity, peptide content, and other critical specifications is provided with every shipment to support your research and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. Due to its hygroscopic (moisture-sensitive) nature, the product should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term stability, store under inert atmosphere or in aliquots to minimize freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by AAA)
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Biological Activity	Assessed by receptor binding assay; data available on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.