Description

4-(2,2-Difluoroethoxy)Benzaldehyde is a versatile fluorinated aromatic aldehyde building block, distinguished by its difluoroethoxy side chain. This compound is crucial for introducing specific fluorine-containing motifs into target molecules, enhancing their physicochemical and metabolic properties. It is primarily sought after by researchers and manufacturers in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and antiviral research where the difluoroethoxy group can improve bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the fluorine atoms contribute to enhanced activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated compounds for electronic displays and organic light-emitting diodes (OLEDs), where specific fluorine patterns are critical for performance.
• Polymer & Material Science: Employed as a monomer or cross-linking agent to introduce fluorine into polymers, potentially altering surface energy, chemical resistance, and optical properties.
• Organic Synthesis & Catalysis: Acts as a versatile electrophile in cross-coupling reactions, condensations, and as a substrate for exploring new fluorination methodologies in academic and industrial R&D.

Basic Information

Product Name	4-(2,2-Difluoroethoxy)Benzaldehyde
CAS No.	128140-72-7
Molecular Formula	C9H8F2O2
Molecular Weight	186.16 g/mol
Synonyms	p-(2,2-Difluoroethoxy)benzaldehyde; 4-(2,2-Difluoroethoxy)benzaldehyde; Benzaldehyde, 4-(2,2-difluoroethoxy)-; 1-(Difluoroethoxy)-4-formylbenzene; 4-Formylphenyl 2,2-difluoroethyl ether
EINECS	Contact for details

Quality Control

Our 4-(2,2-Difluoroethoxy)Benzaldehyde is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support compliance with cGMP, ISO, and other relevant regulatory frameworks for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C) under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation. Keep away from strong oxidizing agents, strong bases, and heat sources.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.