Description

2-Cyclopentene-1-Methanol, 4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-, cis- is a sophisticated nucleoside analog derivative, serving as a critical advanced pharmaceutical intermediate (API) in modern drug discovery and development. Its molecular architecture, featuring a modified purine base linked to a functionalized cyclopentene ring, makes it a valuable building block for the synthesis of novel antiviral and anticancer therapeutics. This high-purity compound is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in producing targeted, small-molecule drugs.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel nucleoside analog drugs targeting viral infections and specific cancer pathways.
• Antiviral Drug Research: Used in the research and development of next-generation antiviral agents, potentially for hepatitis or other viral diseases.
• Oncology Therapeutics: Serves as a precursor in the creation of purine-based compounds designed to inhibit specific enzymes or pathways in cancer cells.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies to understand cellular processes involving purine metabolism.
• Fine Chemical Synthesis: Utilized in multi-step organic synthesis for constructing complex molecules with specific stereochemistry due to its cis-configured cyclopentene moiety.
• Pre-clinical Candidate Development: Integral in the medicinal chemistry phase for optimizing drug-like properties, potency, and selectivity of candidate molecules.

Basic Information

Item	Detail
Product Name	2-Cyclopentene-1-Methanol, 4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-, cis-
CAS No.	128131-83-9
Molecular Formula	C14H18N6O
Molecular Weight	286.33 g/mol
Synonyms	cis-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol; 9-[(1S,4R)-4-(Hydroxymethyl)-2-cyclopenten-1-yl]-2-amino-6-(cyclopropylamino)purine; Carbovir intermediate analog; Cyclopentenylguanine derivative; NSC 684642; A purine nucleoside analog intermediate; 2-Amino-6-cyclopropylamino-9-[(1S,4R)-4-(hydroxymethyl)-2-cyclopenten-1-yl]purine
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent cGMP (current Good Manufacturing Practice) guidelines to ensure batch-to-batch consistency and traceability. Quality is verified through a comprehensive suite of analytical techniques including HPLC for purity and impurity profiling, NMR for structural confirmation, and MS for identity. A detailed Certificate of Analysis (COA) documenting purity, chiral purity, residual solvents, and other critical parameters is provided with each batch.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) when opening the primary container to prevent degradation. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% cis-isomer
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.