Description

H-Gly-Gly-His-Gly-OH is a synthetic tetrapeptide sequence containing the amino acids glycine, glycine, histidine, and glycine. This compound is of significant interest in biochemical research and pharmaceutical development due to its structural role as a model for metal-binding sites in proteins and enzymes. It serves as a critical intermediate and research tool for scientists in pharmaceutical R&D, proteomics, and bioinorganic chemistry who are studying peptide-metal interactions, enzyme mimics, and novel therapeutic agents.

Application

• Biochemical Research: Used as a model peptide to study the coordination chemistry of histidine residues with metal ions like copper, zinc, and nickel.
• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of more complex peptides and potential drug candidates.
• Enzyme Mimic Development: Investigated for creating synthetic enzymes or catalysts that replicate the function of natural metalloenzymes.
• Proteomics & Peptide Libraries: Employed in the construction of peptide arrays and libraries for high-throughput screening and binding studies.
• Academic & Industrial R&D: A fundamental reagent for universities and biotech companies exploring bioinorganic chemistry and peptide-based materials.
• Reference Standard: Utilized as a purity standard in analytical method development for peptide characterization.

Basic Information

Product Name	H-Gly-Gly-His-Gly-OH
CAS No.	128114-56-7
Molecular Formula	C14H21N7O6
Molecular Weight	383.36 g/mol
Synonyms	Glycyl-glycyl-histidyl-glycine; GGHG; H-GGGH-OH; Tetrapeptide GGHG; Gly-Gly-His-Gly; GGHG peptide; L-Histidylglycylglycylglycine; (Gly)2-His-Gly
EINECS	Contact for details

Quality Control

Our H-Gly-Gly-His-Gly-OH is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. All batches are accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to rigorous internal quality standards and can support development projects requiring specific grade qualifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Assay (HPLC)	≥ 95.0%
Purity (HPLC)	≥ 98.0%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.