Description

Fmoc-o-tert-Butyl-D-Serine is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound is specifically designed to incorporate D-serine into peptide chains while providing orthogonal protection for the side-chain hydroxyl group, preventing unwanted side reactions during synthesis. It is a critical building block for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing novel peptide-based therapeutics, diagnostics, and research reagents.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated synthesis of complex peptides containing D-serine residues.
• Pharmaceutical Intermediate: Used in the research and development of peptide drugs, including hormone analogs, antimicrobial peptides, and targeted therapeutics.
• Combinatorial Chemistry: Serves as a building block in libraries for drug discovery and high-throughput screening.
• Bioconjugation: Facilitates the site-specific modification of peptides and proteins for creating antibody-drug conjugates (ADCs) or diagnostic probes.
• Academic & Industrial Research: Essential for studying peptide structure-activity relationships (SAR) and developing new synthetic methodologies.

Basic Information

Product Name	Fmoc-o-tert-Butyl-D-Serine
CAS No.	128107-47-1
Molecular Formula	C₂₂H₂₅NO₅
Molecular Weight	383.44 g/mol
Synonyms	Fmoc-D-Ser(OtBu)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-(tert-butyl)-D-serine; Fmoc-D-Serine(O-tert-butyl); (R)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-((tert-butoxy)oxy)propanoic acid; N-Fmoc-O-tert-butyl-D-serine; Fmoc-D-Ser(tBu)-OH; Fmoc-D-Ser(O-tBu)-OH; Fmoc-D-Ser(OtBu)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-o-tert-Butyl-D-Serine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral analysis, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee consistent quality, reliability, and traceability for your critical research and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccant.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.5%
Optical Rotation	-15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.