Description

H-Phe-Gln-Val-Val-Cys(Npys)-Gly-Nh2 is a synthetic peptide sequence featuring a nitropyridinesulfenyl (Npys) protected cysteine residue, which is a key functional group for selective disulfide bond formation. This compound matters as a critical intermediate and building block in advanced peptide synthesis, enabling the precise construction of complex biomolecules. It is primarily needed by researchers and manufacturers in the pharmaceutical and biotechnology industries for applications in drug discovery, peptide-based therapeutic development, and biochemical research.

Application

• Peptide Synthesis Intermediate: A key building block for the solid-phase or solution-phase synthesis of longer, more complex peptide chains.
• Disulfide Bond Formation: The Npys-protected cysteine allows for controlled, site-specific formation of disulfide bridges, which are crucial for the tertiary structure and biological activity of many peptides and proteins.
• Pharmaceutical Research: Used in the discovery and development of novel peptide-based therapeutics, including hormone analogs, enzyme inhibitors, and targeted drug delivery systems.
• Bioconjugation: Serves as a handle for the selective conjugation of peptides to other molecules, such as fluorescent dyes, polymers, or drug payloads.
• Biochemical Tool Development: Employed in creating probes and standards for studying protein-protein interactions, enzyme kinetics, and receptor binding assays.
• Structure-Activity Relationship (SAR) Studies: Integral for modifying peptide sequences to understand and optimize their biological function and stability.

Basic Information

Product Name	H-Phe-Gln-Val-Val-Cys(Npys)-Gly-Nh2
CAS No.	128102-74-9
Molecular Formula	C34H48N8O8S2
Molecular Weight	760.92 g/mol
Synonyms	FQVV-Cys(Npys)-G-NH2; H-Phe-Gln-Val-Val-Cys(Npys)-Gly-amide; L-Phenylalanyl-L-glutaminyl-L-valyl-L-valyl-S-(2-nitropyridinesulfenyl)-L-cysteinylglycinamide; FQVV-Cys(Npys)-Gly-NH2; S-(2-Nitro-4-pyridinesulfenyl)cysteine-containing pentapeptide amide; Peptide Sequence: Phe-Gln-Val-Val-Cys(Npys)-Gly-NH2; Npys-protected cysteine peptide
EINECS	Contact for details

Quality Control

Our peptide products are manufactured under strict quality management systems. Each batch of H-Phe-Gln-Val-Val-Cys(Npys)-Gly-Nh2 undergoes rigorous analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. We ensure compliance with relevant industry standards for research-grade materials. Certificates of Analysis (COA) detailing purity, identity, and other critical parameters are available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep desiccated under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Assay (Peptide Content)	≥ 80%
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.