Description

2',3'-Bis(o-T-Butyldimethylsilyl)-4',5'-Didehydro-5'-Deoxyuridine is a sophisticated, protected nucleoside derivative designed for advanced synthetic chemistry. This compound is a critical high-purity building block for the synthesis of modified oligonucleotides and nucleotide analogs. It is essential for researchers and manufacturers in pharmaceutical development, particularly in creating novel antiviral and anticancer therapeutics, as well as in specialized biochemical research.

Application

• Pharmaceutical Intermediate: A key protected precursor in the synthesis of novel nucleoside-based antiviral and anticancer drug candidates.
• Oligonucleotide Synthesis: Used in solid-phase and solution-phase synthesis to incorporate modified uridine residues into DNA/RNA strands for research and therapeutic applications.
• Prodrug Development: Serves as a masked intermediate for creating prodrugs with improved bioavailability and targeted delivery.
• Biochemical Research: Employed in studies of nucleic acid structure, function, and enzyme interactions due to its specific chemical modifications.
• Antisense Technology: A valuable component for creating antisense oligonucleotides designed to modulate gene expression.
• Labeled Nucleotide Production: Acts as a starting material for synthesizing nucleotides tagged with fluorescent or other reporter molecules.

Basic Information

Item	Detail
Product Name	2',3'-Bis(o-T-Butyldimethylsilyl)-4',5'-Didehydro-5'-Deoxyuridine
CAS No.	128070-78-0
Molecular Formula	C21H40N2O5Si2
Molecular Weight	456.73 g/mol
Synonyms	2',3'-Bis-O-(tert-butyldimethylsilyl)-4',5'-didehydro-5'-deoxyuridine; 5'-Deoxy-2',3'-O-bis(tert-butyldimethylsilyl)-4',5'-didehydrouridine; TBDMS-protected 5'-deoxyuridine derivative; 2',3'-Di-O-TBDMS-4',5'-didehydro-5'-deoxyuridine; 4',5'-Didehydro-5'-deoxy-2',3'-O-[(1,1-dimethylethyl)dimethylsilyl]uridine; Protected d4U derivative; CAS 128070-78-0
EINECS	Contact for details

Quality Control

Every batch of 2',3'-Bis(o-T-Butyldimethylsilyl)-4',5'-Didehydro-5'-Deoxyuridine is manufactured under strict quality systems. We provide comprehensive analytical documentation to ensure reproducible performance in sensitive synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions. Keep away from strong alkalis and fluorides.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.