Description

Lorazepam Hemisuccinate is a key pharmaceutical intermediate, specifically the hemisuccinate ester salt of the well-known benzodiazepine, lorazepam. This compound is valued for its role in enhancing the solubility and bioavailability of the active pharmaceutical ingredient in various formulations. It is primarily utilized by pharmaceutical manufacturers and research organizations engaged in the development and production of advanced anxiolytic and sedative medications.

Application

• Active Pharmaceutical Ingredient (API) Intermediate: A critical precursor in the synthesis of Lorazepam and its derivative formulations.
• Pharmaceutical Research & Development: Used in preclinical and clinical studies for developing new benzodiazepine-based therapeutics.
• Formulation Enhancement: Employed to improve the solubility and stability of injectable or oral dosage forms.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory testing in pharmaceutical labs.
• Chemical Synthesis: Acts as a building block for the preparation of other specialized ester derivatives for pharmacological evaluation.

Basic Information

Product Name	Lorazepam Hemisuccinate
CAS No.	127930-80-7
Molecular Formula	C₂₂H₁₉ClN₂O₆
Molecular Weight	442.85 g/mol
Synonyms	Lorazepam hydrogen succinate; 7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one hemisuccinate; Lorazepam 3-hemisuccinate; UNII-8O1W8R6ZGP; Lorazepam succinate; Lorazepam acid succinate
EINECS	Contact for details

Quality Control

Our Lorazepam Hemisuccinate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and impurity profiles, suitable for pharmaceutical applications. Certificates of Analysis (COA) documenting all test results are provided to guarantee traceability and compliance with customer requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.