Description

(E)-(+/-)-2-Amino-4-Methyl-5-Phosphono-3-Pentenoic Acid is a specialized, non-proteinogenic amino acid analog featuring a phosphonate group, which is of significant interest in biochemical and pharmacological research. This compound matters as a potent and selective antagonist for glutamate receptors, particularly within the NMDA receptor complex, making it a critical tool for studying neurological pathways. It is primarily needed by research institutions and pharmaceutical developers focused on neuroscience, neuroprotection, and the development of novel therapeutic agents for conditions like stroke, epilepsy, and neurodegenerative diseases.

Application

• Neuroscience Research: As a selective NMDA receptor antagonist for studying excitatory neurotransmission, synaptic plasticity, and neuronal cell death.
• Pharmacological Development: Serving as a key reference standard or lead compound in the design of neuroprotective agents and treatments for neurological disorders.
• Biochemical Studies: Used in enzyme inhibition assays and to investigate the role of glutamate analogs in metabolic pathways.
• Academic & Institutional Research: A vital reagent for universities and R&D labs exploring the mechanisms of brain ischemia, pain, and memory.
• Diagnostic Tool Development: Potential use in developing assays and probes for glutamate receptor characterization and binding studies.

Basic Information

Product Name	(E)-(+/-)-2-Amino-4-Methyl-5-Phosphono-3-Pentenoic Acid
CAS No.	127910-31-0
Molecular Formula	C6H12NO5P
Molecular Weight	209.14 g/mol
Synonyms	2-Amino-4-methyl-5-phosphono-3-pentenoic acid; (E)-2-Amino-4-methyl-5-phosphono-3-pentenoic acid; (±)-CGP 40116; CGP-40116; CGP40116; (E)-AP5; DL-AP5; NMDA receptor antagonist CGP 40116; (E)-2-Amino-4-methyl-5-phosphonopent-3-enoic acid
EINECS	Contact for details

Quality Control

Our high-purity (E)-(+/-)-2-Amino-4-Methyl-5-Phosphono-3-Pentenoic Acid is manufactured under strict quality systems to ensure batch-to-batch consistency for critical research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and Mass Spectrometry. A detailed Certificate of Analysis (COA) is provided, documenting purity, assay, and impurity profiles to meet the stringent requirements of pharmaceutical and academic research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	97.0% - 102.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.