Description

Thyrotropin-Releasing Hormone, 2,4-Mepro(3)- CAS NO 127902-57-2 is a synthetic analogue of the endogenous thyrotropin-releasing hormone (TRH), a key neuropeptide involved in the hypothalamic-pituitary-thyroid axis. This modified peptide is engineered for enhanced metabolic stability and receptor specificity, making it a critical tool for advanced endocrinology research and diagnostic development. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and diagnostic manufacturers focused on neuroendocrine function, thyroid disorders, and peptide-based therapeutic discovery.

Application

• Neuroendocrine Research: Used as a reference standard and probe to study the regulation of TSH and prolactin secretion in vitro and in vivo models.
• Diagnostic Kit Development: Serves as a key antigen or calibrator in immunoassays for measuring TRH levels or related antibodies.
• Drug Discovery & Screening: Employed in high-throughput screening (HTS) assays to identify and characterize novel TRH receptor agonists or antagonists.
• Pharmacological Studies: Investigates the central nervous system effects of TRH analogues, including potential applications in neurological conditions.
• Biochemical Standardization: Acts as a purity standard for quality control in the production of other peptide hormones or related biopharmaceuticals.
• Academic & Clinical Research: Supports fundamental studies on thyroid physiology, hormone release mechanisms, and peptide stability.

Basic Information

Product Name	Thyrotropin-Releasing Hormone, 2,4-Mepro(3)- CAS NO 127902-57-2
CAS No.	127902-57-2
Molecular Formula	C16H22N6O4
Molecular Weight	362.38 g/mol
Synonyms	TRH Analogue, 2,4-Mepro(3)-TRH; 2,4-Dimethylproline3-TRH; Pyroglutamyl-Histidyl-(2,4-dimethylprolinamide); (2S,4R)-4-Methylproline3-Thyrotropin-Releasing Hormone; Lopremone analogue; Protirelin analogue; 2,4-Mepro3-TRH; Thyroliberin analogue, 2,4-dimethylproline modification
EINECS	Contact for details

Quality Control

Our Thyrotropin-Releasing Hormone, 2,4-Mepro(3)- is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis, to ensure it meets the high standards required for research and diagnostic applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic (moisture-sensitive) nature, the product should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term stability, store under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%
Solubility	Soluble in water, dimethyl sulfoxide

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.