Description

(S)-1-[3-(Trifluoromethyl)Phenyl]Ethylamine is a high-value chiral amine building block featuring a trifluoromethylphenyl group, which imparts unique physicochemical properties to final compounds. This compound is critical for pharmaceutical and agrochemical research, where its stereochemistry and fluorine content are leveraged to enhance metabolic stability, bioavailability, and binding affinity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of active ingredients and functional intermediates.

Application

• Key chiral intermediate in the synthesis of pharmaceutical active ingredients (APIs), particularly for central nervous system (CNS) and metabolic disorder targets.
• Building block for creating advanced agrochemicals, such as herbicides and fungicides, where the trifluoromethyl group improves efficacy and environmental profile.
• Precursor in the development of chiral ligands and catalysts used in asymmetric synthesis.
• Starting material for research into novel liquid crystals and organic electronic materials.
• Intermediate for the preparation of bioactive molecules in preclinical and discovery-phase chemistry.
• Used in the synthesis of fluorinated analogs for structure-activity relationship (SAR) studies.

Basic Information

Product Name	(S)-1-[3-(Trifluoromethyl)Phenyl]Ethylamine
CAS No.	127852-21-5
Molecular Formula	C9H10F3N
Molecular Weight	189.18 g/mol
Synonyms	(S)-1-(3-Trifluoromethylphenyl)ethylamine; (S)-α-Methyl-3-(trifluoromethyl)benzeneethanamine; (S)-3'-(Trifluoromethyl)phenethylamine; (S)-1-(3-(Trifluoromethyl)phenyl)ethan-1-amine; (S)-1-(m-Trifluoromethylphenyl)ethylamine; (S)-m-Trifluoromethyl-α-methylbenzylamine; (S)-1-[3-(Trifluoromethyl)phenyl]ethanamine
EINECS	Contact for details

Quality Control

Our (S)-1-[3-(Trifluoromethyl)Phenyl]Ethylamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess and GC/HPLC for chemical purity, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation and maintain purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.