Description

3,6-Dibromo-1,5-Dihydro-1-(2,3,5-Tri-o-Benzoyl--D-Ribofuranosyl)-4H-Pyrazolo[3,4-D]Pyrimidin-4-One is a sophisticated nucleoside analog building block, specifically designed for advanced pharmaceutical research and development. This compound is critical for medicinal chemists working on novel antiviral and anticancer therapeutics, particularly those targeting nucleoside metabolic pathways. It is primarily utilized by R&D laboratories and fine chemical manufacturers in the pharmaceutical and biotechnology sectors for the synthesis of modified nucleosides and oligonucleotides.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel nucleoside-based antiviral and anticancer drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop new therapeutic agents targeting DNA/RNA polymerases.
• Biochemical Probe Development: Serves as a modified nucleoside precursor for creating probes to study enzyme mechanisms and nucleic acid interactions.
• Oligonucleotide Synthesis: Acts as a protected, modified nucleoside phosphoramidite precursor for the solid-phase synthesis of specialized oligonucleotides.
• Antiviral Agent Development: Particularly relevant for research into treatments for viral infections where nucleoside analogs are a primary therapeutic strategy.

Basic Information

Product Name	3,6-Dibromo-1,5-Dihydro-1-(2,3,5-Tri-o-Benzoyl--D-Ribofuranosyl)-4H-Pyrazolo[3,4-D]Pyrimidin-4-One
CAS No.	127820-68-2
Molecular Formula	C31H22Br2N4O7
Molecular Weight	722.34 g/mol
Synonyms	3,6-Dibromo-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one; 6-Bromo-3-bromo-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one; 1-(2,3,5-Tri-O-benzoyl-β-D-ribofuranosyl)-3,6-dibromo-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one; Tribenzoyl-3,6-dibromopyrazolopyrimidine ribonucleoside; Modified nucleoside intermediate 127820-68-2
EINECS	Contact for details

Quality Control

Our production of this advanced pharmaceutical intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, identity, and impurity profiles. We support development and cGMP-grade requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment. For long-term storage, consider desiccation or storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.