Description

(R)-1-[3,5-Bis(Trifluoromethyl)Phenyl]Ethylamine is a high-value, chiral amine building block characterized by its electron-deficient aromatic system. This compound is essential for the synthesis of advanced pharmaceutical intermediates and fine chemicals, where its trifluoromethyl groups impart unique metabolic stability and lipophilicity. It is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and catalysts.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of NK1 receptor antagonists, such as Aprepitant and Fosaprepitant, used for chemotherapy-induced nausea and vomiting (CINV).
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the trifluoromethyl groups enhance biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a backbone for creating chiral ligands and organocatalysts used in asymmetric synthesis, crucial for producing enantiomerically pure compounds.
• Material Science Research: Employed in the development of specialty polymers and advanced organic materials with specific electronic properties.
• Chemical Biology Probes: Utilized in the design of molecular probes and inhibitors for studying enzyme function and biological pathways.

Basic Information

Product Name	(R)-1-[3,5-Bis(Trifluoromethyl)Phenyl]Ethylamine
CAS No.	127733-47-5
Molecular Formula	C10H7F6N
Molecular Weight	255.16 g/mol
Synonyms	(R)-[3,5-Bis(trifluoromethyl)phenyl]ethylamine; (R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethanamine; (R)-α-Methyl[3,5-bis(trifluoromethyl)benzene]methanamine; (R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethylamine; (R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethan-1-amine; (R)-3,5-Bis(trifluoromethyl)phenethylamine; (R)-Aprepitant Intermediate
EINECS	Contact for details

Quality Control

Our (R)-1-[3,5-Bis(Trifluoromethyl)Phenyl]Ethylamine is manufactured under strict quality systems to ensure batch-to-batch consistency for critical R&D and scale-up processes. We provide comprehensive analytical data, including chiral purity (enantiomeric excess) verification by HPLC. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Enantiomeric Excess)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.