Description

(R)-1-[3,5-Bis(Trifluoromethyl)Phenyl]Ethylamine Hcl CAS NO 127733-40-8 is a high-value chiral amine building block characterized by its trifluoromethylated aromatic structure. This compound is essential for pharmaceutical and agrochemical research, where its unique stereochemistry and fluorine atoms are leveraged to modulate the biological activity, metabolic stability, and lipophilicity of target molecules. It is primarily sought by R&D chemists and process development scientists in the fine chemical and contract manufacturing sectors for the synthesis of advanced intermediates and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel therapeutics, particularly in central nervous system (CNS) and oncology drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethyl groups enhance efficacy and environmental persistence.
• Catalyst and Ligand Preparation: Serves as a precursor for chiral catalysts and ligands used in asymmetric synthesis.
• Material Science Research: Employed in the development of specialty polymers and advanced organic materials with specific electronic or surface properties.
• Academic & Institutional Research: A valuable reagent for methodological studies in organic chemistry and medicinal chemistry programs.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring enantiomerically pure, fluorinated aromatic amines.

Basic Information

Item	Details
Product Name	(R)-1-[3,5-Bis(Trifluoromethyl)Phenyl]Ethylamine Hydrochloride
CAS No.	127733-40-8
Molecular Formula	C10H8F6N·HCl
Molecular Weight	283.63 g/mol (Free base: 247.17 g/mol)
Synonyms	(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanamine hydrochloride; (R)-α-Methyl[3,5-bis(trifluoromethyl)phenyl]methylamine HCl; (R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethylamine hydrochloride; (R)-3,5-Bis(trifluoromethyl)phenethylamine hydrochloride; (R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethan-1-amine hydrochloride; (R)-[3,5-Bis(trifluoromethyl)phenyl]ethylamine HCl; (R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethylammonium chloride
EINECS	Contact for details

Quality Control

Our (R)-1-[3,5-Bis(Trifluoromethyl)Phenyl]Ethylamine HCl is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing to ensure high chiral purity and chemical integrity, meeting the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.