Description

4,6-Dichloro-2-(Methylsulfonyl)-5-Nitropyrimidine is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. Its unique structure, featuring reactive chloro, nitro, and methylsulfonyl groups, makes it a critical intermediate for constructing complex molecules with precision. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

This versatile pyrimidine derivative serves as a key synthetic intermediate in several high-value applications:

• Pharmaceutical Intermediate: Core building block for the synthesis of potential drug candidates, including kinase inhibitors, antiviral agents, and other biologically active heterocycles.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging its reactive sites for structural diversification.
• Material Science Research: Acts as a precursor for creating specialized polymers, ligands, or functional materials that require a nitropyrimidine backbone.
• Chemical Biology & Proteomics: May be utilized in the design of activity-based probes or affinity tags due to its electrophilic centers that can react with nucleophilic amino acids.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Item	Details
Product Name	4,6-Dichloro-2-(Methylsulfonyl)-5-Nitropyrimidine
CAS No.	127726-62-9
Molecular Formula	C5H3Cl2N3O4S
Molecular Weight	267.06 g/mol
Synonyms	2-(Methylsulfonyl)-4,6-dichloro-5-nitropyrimidine; 4,6-Dichloro-5-nitro-2-(methylsulfonyl)pyrimidine; 5-Nitro-4,6-dichloro-2-methylsulfonylpyrimidine; 127726-62-9; 4,6-Dichloro-2-methanesulfonyl-5-nitropyrimidine; 2-(Methanesulfonyl)-4,6-dichloro-5-nitropyrimidine
EINECS	Contact for details

Quality Control

Our production of 4,6-Dichloro-2-(Methylsulfonyl)-5-Nitropyrimidine adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability for your critical research and development processes. Each lot undergoes comprehensive analytical characterization using techniques such as HPLC, NMR, and MS to confirm identity and purity. Certificates of Analysis (COA) detailing all relevant specifications are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.