Description

Helothermine is a bioactive peptide toxin isolated from the venom of the Mexican beaded lizard (*Heloderma horridum*). This compound is a critical research tool for studying the structure and function of potassium (K+) channels, particularly the Kv1.1, Kv1.2, and Kv1.3 subtypes. As a high-purity biochemical, it is essential for neuroscientists, pharmacologists, and toxicologists engaged in ion channel research, drug discovery for neurological disorders, and the development of novel therapeutic agents.

Application

• Neuroscience Research: A selective blocker used to investigate the physiological and pathological roles of voltage-gated potassium channels in neuronal signaling and excitability.
• Drug Discovery & Pharmacology: Serves as a molecular probe for screening and validating new compounds targeting potassium channels for conditions like epilepsy, autoimmune diseases, and chronic pain.
• Toxicology & Venom Studies: Used as a reference standard in the study of reptile venoms, their mechanisms of action, and the development of antivenoms.
• Biochemical Assay Development: Employed in the development and calibration of functional cell-based assays and binding assays for ion channel activity.
• Academic & Institutional Research: Fundamental reagent for university and government laboratories studying ion channel biophysics and structure-activity relationships (SAR).

Basic Information

Product Name	Helothermine
CAS No.	127670-24-0
Molecular Formula	C254H383N73O73S9
Molecular Weight	~5960 g/mol
Synonyms	Helothermine peptide; Heloderma horridum toxin; Potassium channel blocker toxin HL-1; ShK-like toxin from Heloderma; SVSP-1; Helothermine (Heloderma horridum horridum); Beaded lizard toxin; K+ channel toxin HL-1
EINECS	Contact for details

Quality Control

Our Helothermine is produced and handled under strict quality protocols to ensure batch-to-batch consistency and biological activity. Each lot is characterized using advanced analytical techniques, including HPLC for purity assessment and mass spectrometry for identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, potency (where applicable), and analytical results is provided with every shipment to support your research integrity and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized powder at -20°C or below. Reconstituted solutions should be aliquoted and stored at -80°C to avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (Mass Spec)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Biological Activity	Confirmed by functional assay (Data on COA)
Endotoxin Level	< 1.0 EU/µg
Solubility	Soluble in aqueous buffers or DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.