Description

Neurokinin A, Ala(5)-Aib(8)-Leu(10)- CAS NO 127627-57-0 is a synthetic, biologically active peptide analog of the endogenous tachykinin Neurokinin A, engineered with specific amino acid substitutions to enhance its stability and receptor selectivity. This modified peptide is a critical research tool for investigating the complex signaling pathways of the neurokinin system, particularly the NK2 receptor subtype. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on neuroscience, pain management, and inflammatory disease research.

Application

• Neuroscience Research: A key ligand for studying the physiological and pathological roles of the Neurokinin/NK2 receptor system in the central and peripheral nervous systems.
• Pharmacological Assay Development: Used as a reference standard or active agent in high-throughput screening (HTS) and functional assays to identify and characterize novel NK2 receptor antagonists or agonists.
• Signal Transduction Studies: Employed to elucidate downstream signaling cascades, such as calcium mobilization and IP3 accumulation, activated by NK2 receptor binding.
• Drug Discovery & Preclinical Studies: Serves as a tool compound for validating animal models of pain, inflammation, and gastrointestinal motility disorders where the NK2 pathway is implicated.
• Biochemical Reagent: Used in receptor binding studies (competitive displacement assays) to determine binding affinities (Ki/IC50 values) of new chemical entities.
• Peptide Structure-Activity Relationship (SAR) Research: The specific Ala, Aib (aminoisobutyric acid), and Leu substitutions make it a valuable compound for studying the impact of peptide backbone modification on biological activity and metabolic stability.

Basic Information

Product Name	Neurokinin A, Ala(5)-Aib(8)-Leu(10)-
CAS No.	127627-57-0
Molecular Formula	C58H91N17O14S
Molecular Weight	1250.5 g/mol
Synonyms	[Ala5, Aib8, Leu10]-Neurokinin A; Neurokinin A (4-10), Ala5, Aib8, Leu10 analog; H-His-Lys-Thr-Asp-Ala-Phe-Aib-Gly-Leu-Leu-NH2; Modified Neurokinin A fragment; NK2 receptor selective peptide analog; Tachykinin peptide analog; NKA (4-10) analog
EINECS	Contact for details

Quality Control

Our Neurokinin A analog is manufactured under strict quality systems to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and mass spectrometry (MS) for identity confirmation. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data on purity, peptide content, and solubility. Our quality commitment aligns with standards expected for research-grade biochemicals.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. Aliquot into smaller working quantities to minimize freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Analysis	Within ± 10% of theoretical
Solubility	Soluble in water, dilute acetic acid, or DMSO
Water Content (KF)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.