Description

Alpha,β-Dimethylhistamine is a synthetic histamine analog characterized by the addition of two methyl groups to the histamine structure. This modification is of significant interest in pharmacological research for studying and modulating histamine receptor activity. It serves as a key intermediate and reference standard in the development of novel therapeutic agents targeting the central nervous system and inflammatory pathways. Researchers and pharmaceutical developers in medicinal chemistry and drug discovery utilize this compound for its specific receptor-binding properties.

Application

• Pharmacological Research: Acts as a reference standard and tool compound for studying histamine H1, H2, and H3 receptor subtypes.
• Medicinal Chemistry: Serves as a critical synthetic intermediate in the development of new histamine receptor agonists and antagonists.
• Neuroscience Studies: Used in vitro and in vivo models to investigate the role of histaminergic systems in sleep, cognition, and appetite regulation.
• Drug Discovery: A building block for creating novel compounds with potential applications in treating allergies, gastrointestinal disorders, and neurological conditions.
• Biochemical Assays: Employed in high-throughput screening (HTS) and binding assays to identify and characterize new drug candidates.
• Academic Research: Utilized in university and institutional labs for fundamental research on G-protein coupled receptors (GPCRs).

Basic Information

Product Name	Alpha,β-Dimethylhistamine
CAS No.	127607-85-6
Molecular Formula	C7H13N3
Molecular Weight	139.20 g/mol
Synonyms	α,β-Dimethylhistamine; 2-(1H-Imidazol-4-yl)-N,N-dimethylethanamine; 4-(2-Dimethylaminoethyl)imidazole; Histamine, α,β-dimethyl-; Dimethylhistamine; NSC 339524; 1H-Imidazole-4-ethanamine, N,N-dimethyl-
EINECS	Contact for details

Quality Control

Our Alpha,β-Dimethylhistamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and spectroscopic identification (NMR, IR, MS), to ensure it meets the high standards required for research and development. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.