Description

1-Methyl-5-(3-Azido-2,3-Dideoxy-β-Pentofuranosyl)Uracil is a specialized nucleoside analogue, a key building block in medicinal chemistry and life science research. This compound is valued for its role as a modified nucleic acid component, enabling the study and development of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on antiviral and anticancer drug discovery, as well as in academic research exploring nucleotide biochemistry.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel nucleoside-based antiviral and anticancer agents.
• Biochemical Research: Used as a modified substrate to study enzyme mechanisms, polymerase activity, and nucleic acid metabolism.
• Probe Development: Serves as a building block for creating labeled nucleotides or probes for diagnostic assays and genomic studies.
• Antisense Oligonucleotide Synthesis: Incorporated into oligonucleotide chains to modulate stability, binding affinity, and biological activity.
• Medicinal Chemistry Libraries: A valuable scaffold for generating compound libraries in high-throughput screening for drug discovery programs.

Basic Information

Product Name	1-Methyl-5-(3-Azido-2,3-Dideoxy-β-Pentofuranosyl)Uracil
CAS No.	127517-38-8
Molecular Formula	C10H13N5O5
Molecular Weight	283.24 g/mol
Synonyms	3'-Azido-3'-deoxy-5-methyluridine; 1-Methyl-5-(3-azido-2,3-dideoxy-β-D-ribofuranosyl)uracil; 3'-Azido-3'-deoxythymidine analogue; AZT-Uracil Derivative; 3'-N3-5-Methyl-2',3'-dideoxyuridine; 5-Methyl-1-((2R,5S)-5-(azidomethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
EINECS	Contact for details

Quality Control

Our 1-Methyl-5-(3-Azido-2,3-Dideoxy-β-Pentofuranosyl)Uracil is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed specifications are provided to guarantee traceability, consistency, and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.