Description

Conantokin-T is a selective and potent antagonist of the N-methyl-D-aspartate (NMDA) receptor, specifically targeting the NR2B subunit. This compound is a valuable research-grade neurochemical tool derived from cone snail venom, used extensively in neuroscience and pharmacological studies. It is essential for researchers and pharmaceutical developers investigating neurological pathways, excitotoxicity, and potential treatments for conditions like stroke, chronic pain, and neurodegenerative diseases.

Application

• Neuroscience Research: A critical tool for studying the function and modulation of NMDA receptors, particularly the NR2B subtype, in synaptic plasticity and signal transduction.
• Pharmacological Development: Used in high-throughput screening and target validation for drug discovery programs focused on neurological disorders.
• Neuroprotection Studies: Employed in experimental models to understand mechanisms of excitotoxicity and to evaluate potential neuroprotective agents.
• Biochemical Assays: Serves as a reference standard in receptor binding assays and functional studies to characterize new compounds.
• Academic & Institutional Research: Utilized in university and government labs for fundamental research into glutamate receptor biology and CNS function.

Basic Information

Product Name	Conantokin-T
CAS No.	127476-26-0
Molecular Formula	C95H147N31O27S2
Molecular Weight	2268.6 g/mol
Synonyms	Con-T; Conantokin T; γ-carboxyglutamate-containing conantokin-T; NR2B-selective NMDA receptor antagonist; Conantokin from Conus tulipa; Conantokin T peptide
EINECS	Contact for details

Quality Control

Our Conantokin-T is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and MS for identity confirmation. A Certificate of Analysis (COA) detailing purity, peptide content, and solvent residues is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Solvent Residues	Meets ICH guidelines
Biological Activity	Confirmed by functional assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.