Description

tert-Butyloxycarbonyl-Valyl-Alanyl-Leucyl-2-Aminoisobutyryl-Valyl-Alanyl-Leucyl Methyl Ester CAS NO 127337-62-6 is a protected peptide derivative, specifically a heptapeptide methyl ester featuring a Boc-protected N-terminus and a 2-aminoisobutyryl (Aib) residue. This compound is a critical advanced intermediate in the synthesis of complex peptides and peptidomimetics, valued for its role in constructing specific secondary structures. It is primarily utilized by pharmaceutical R&D and biotechnology organizations focused on developing novel therapeutic agents and studying protein-protein interactions.

Application

• Pharmaceutical Research & Development: Serves as a key building block for the solid-phase or solution-phase synthesis of longer, biologically active peptide sequences targeting various diseases.
• Peptidomimetic Design: The incorporation of the 2-aminoisobutyryl (Aib) residue is crucial for inducing helical conformations, making this intermediate valuable for creating stable peptide mimics with enhanced metabolic stability.
• Bioconjugation & Probe Development: Can be used as a scaffold for attaching labels, tags, or other functional groups to create diagnostic tools or targeted delivery systems.
• Academic Research: Employed in biochemical and biophysical studies to investigate peptide folding, stability, and receptor-ligand interactions.
• Process Development & Scale-up: Used as a reference standard or intermediate in optimizing synthetic routes for GMP-grade peptide active pharmaceutical ingredients (APIs).

Basic Information

Item	Detail
Product Name	tert-Butyloxycarbonyl-Valyl-Alanyl-Leucyl-2-Aminoisobutyryl-Valyl-Alanyl-Leucyl Methyl Ester
CAS No.	127337-62-6
Molecular Formula	C41H72N8O11
Molecular Weight	853.06 g/mol
Synonyms	Boc-Val-Ala-Leu-Aib-Val-Ala-Leu-OMe; Boc-V-A-L-Aib-V-A-L-OMe; Heptapeptide Methyl Ester Boc-VALAL-Aib-VALAL-OMe; N-α-Boc-L-valyl-L-alanyl-L-leucyl-2-aminoisobutyryl-L-valyl-L-alanyl-L-leucine Methyl Ester; (3S,6S,9S,12S,15S,18S,21S)-3,9,15-Triisopropyl-6,12,18,21-tetramethyl-1,4,7,10,13,16,19-heptaoxo-2,5,8,11,14,17,20-heptaazatricosan-23-oic acid methyl ester, N-Boc-protected; Protected Heptapeptide; Aib-containing Peptide Intermediate
EINECS	Contact for details

Quality Control

Every batch of our peptide intermediates is produced and analyzed under a strict quality management system. We employ advanced analytical techniques, including HPLC and mass spectrometry, to ensure high purity and structural integrity. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and related substances is provided with each shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to prevent condensation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0% (on anhydrous basis)
Water Content (KF)	≤ 3.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.