Description

Sitafloxacin CAS NO 127254-12-0 is a potent, broad-spectrum fluoroquinolone antibiotic belonging to the fourth generation of its class. It is valued for its enhanced activity against Gram-positive bacteria, including drug-resistant strains, and atypical pathogens. This compound is a critical active pharmaceutical ingredient (API) primarily required by pharmaceutical manufacturers and research institutions for the development and production of advanced antibacterial therapies.

Application

• Pharmaceutical API: Primary use as the active ingredient in the formulation of oral antibacterial medications.
• Clinical Research: Utilized in preclinical and clinical studies to evaluate efficacy against resistant bacterial infections.
• Veterinary Medicine: Potential application in developing treatments for bacterial infections in animals.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory testing in laboratories.
• Antimicrobial Susceptibility Testing: Used in microbiological assays to determine bacterial resistance profiles.

Basic Information

Product Name	Sitafloxacin
CAS No.	127254-12-0
Molecular Formula	C19H18ClF2N3O3
Molecular Weight	409.81 g/mol
Synonyms	DU-6859a; Sitafloxacin hydrate; (-)-7-[(7S)-7-Amino-5-azaspiro[2.4]heptan-5-yl]-8-chloro-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid; 7-[(7S)-7-Amino-5-azaspiro[2.4]hept-5-yl]-8-chloro-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
EINECS	Contact for details

Quality Control

Our Sitafloxacin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identification by IR and NMR, to ensure it meets stringent pharmaceutical-grade specifications. Certificates of Analysis (COA) documenting full compliance are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (HPLC)	≥98.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤1.5% Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.