Description

7-[(4S)-4-Amino-6-Azaspiro[2.4]Heptan-6-Yl]-8-Chloro-6-Fluoro-1-[(1R,2S)-2-Fluorocyclopropyl]-4-Oxoquinoline-3-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate with a complex molecular architecture designed for targeted activity. This compound is critical for the synthesis of next-generation antibacterial agents, particularly within the fluoroquinolone class, offering a pathway to novel therapeutics. It is an essential building block for pharmaceutical R&D and manufacturing organizations focused on developing innovative anti-infective drugs.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: A key chiral intermediate in the production of novel fluoroquinolone antibiotics.
• Pharmaceutical Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new antibacterial candidates.
• Process Chemistry & Scale-Up: Serves as a critical starting material or intermediate for process optimization and pilot-scale manufacturing.
• Contract Manufacturing (CMO): Supplied to contract development and manufacturing organizations (CDMOs) for cGMP production of drug substances.
• Reference Standard: Utilized as an analytical standard for quality control and regulatory submissions.

Basic Information

Product Name	7-[(4S)-4-Amino-6-Azaspiro[2.4]Heptan-6-Yl]-8-Chloro-6-Fluoro-1-[(1R,2S)-2-Fluorocyclopropyl]-4-Oxoquinoline-3-Carboxylic Acid
CAS No.	127254-10-8
Molecular Formula	C19H18ClF2N3O3
Molecular Weight	409.82 g/mol
Synonyms	7-[(4S)-4-Amino-6-azaspiro[2.4]hept-6-yl]-8-chloro-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; (4S)-6-[8-Chloro-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-4-oxo-1,4-dihydro-3-quinolinecarboxylate]-6-azaspiro[2.4]heptan-4-amine; GSK-2140944 Intermediate; Novel Fluoroquinolone Intermediate; 6-Azaspiro[2.4]heptanequinolinecarboxylic Acid Derivative
EINECS	Contact for details

Quality Control

Our 7-[(4S)-4-Amino-6-Azaspiro[2.4]Heptan-6-Yl]-8-Chloro-6-Fluoro-1-[(1R,2S)-2-Fluorocyclopropyl]-4-Oxoquinoline-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and comprehensive impurity profiling, to ensure it meets the high standards required for pharmaceutical development. Certificates of Analysis (COA) with full traceability are provided and can be tailored to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.