Description

3-(1,3-Dioxolan-2-Yl)-4-Fluoro-Benzenamine is a versatile fluorinated aniline derivative featuring a protected aldehyde functional group. This compound matters as a key chiral building block and intermediate in advanced organic synthesis, offering a unique combination of aromatic amine reactivity and acetal-protected carbonyl functionality. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers for the development of active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of complex drug molecules, particularly those requiring fluorinated aromatic systems.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides where the fluorine atom enhances biological activity and stability.
• Ligand and Catalyst Development: Serves as a starting material for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probes: Useful for constructing fluorescent tags and molecular probes due to its amine handle and modifiable acetal group.
• Custom Synthesis and Contract Manufacturing: A valuable building block for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	3-(1,3-Dioxolan-2-Yl)-4-Fluoro-Benzenamine
CAS No.	127228-82-4
Molecular Formula	C9H10FNO2
Molecular Weight	183.18 g/mol
Synonyms	4-Fluoro-3-(1,3-dioxolan-2-yl)aniline; 4-Fluoro-3-(1,3-dioxolan-2-yl)benzenamine; 2-(2-Fluoro-5-aminophenyl)-1,3-dioxolane; 3-Amino-4-fluorobenzaldehyde ethylene acetal; Benzenamine, 3-(1,3-dioxolan-2-yl)-4-fluoro-; 4-Fluoro-3-(1,3-dioxolan-2-yl)phenylamine
EINECS	Contact for details

Quality Control

Our 3-(1,3-Dioxolan-2-Yl)-4-Fluoro-Benzenamine is produced under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.